日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening

通过大规模并行测序、核糖体展示和亲和力筛选快速发现高亲和力抗体

Benjamin T Porebski, Matthew Balmforth, Gareth Browne, Aidan Riley, Kiarash Jamali, Maximillian J L J Fürst, Mirko Velic, Andrew Buchanan, Ralph Minter, Tristan Vaughan, Philipp Holliger

Characterization of mAbs against Klebsiella pneumoniae type 3 fimbriae isolated in a target-independent phage display campaign

在非靶向噬菌体展示活动中分离的针对肺炎克雷伯菌 3 型菌毛的 mAb 的表征

Sophia K Berry, Steven Rust, Lorraine Irving, Josefin Bartholdson Scott, Lucy A Weinert, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J Grant

Gigavalent Display of Proteins on Monodisperse Polyacrylamide Hydrogels as a Versatile Modular Platform for Functional Assays and Protein Engineering

单分散聚丙烯酰胺水凝胶上的蛋白质千价展示作为功能测定和蛋白质工程的多功能模块化平台

Thomas Fryer, Joel David Rogers, Christopher Mellor, Timo N Kohler, Ralph Minter, Florian Hollfelder

Phenotypic whole-cell screening identifies a protective carbohydrate epitope on Klebsiella pneumoniae

表型全细胞筛选鉴定出肺炎克雷伯菌的保护性碳水化合物表位

Sophia K Berry, Steven Rust, Carolina Caceres, Lorraine Irving, Josefin Bartholdson Scott, David E Tabor, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J Grant

Multiplexed Affinity Characterization of Protein Binders Directly from a Crude Cell Lysate by Covalent Capture on Suspension Bead Arrays

通过在悬浮珠阵列上共价捕获直接从粗细胞裂解物中多重亲和力表征蛋白质结合剂

Tuomas Huovinen, Laurens Lindenburg, Ralph Minter, Florian Hollfelder

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

补体调节因子 H 的受体可增加锥虫向采采蝇的传播

Olivia J S Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J Savill, Svenja Hester, Sophie Ravel, Jack D Sunter, Camilla Trevor, Steven Rust, Tristan J Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C Taylor, Matthew K Higgins, Mark Carrington0

Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion

锥虫转铁蛋白受体的结构揭示了配体识别和免疫逃避的机制

Camilla E Trevor, Andrea L Gonzalez-Munoz, Olivia J S Macleod, Peter G Woodcock, Steven Rust, Tristan J Vaughan, Elspeth F Garman, Ralph Minter, Mark Carrington, Matthew K Higgins

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

使用 DARPin 与变构叶中的位点结合来进行 KRAS 特异性抑制

Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H Rabbitts

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

单剂量抗体-药物偶联物可治愈非洲锥虫病 1 期模型

Paula MacGregor, Andrea L Gonzalez-Munoz, Fatoumatta Jobe, Martin C Taylor, Steven Rust, Alan M Sandercock, Olivia J S Macleod, Katrien Van Bocxlaer, Amanda F Francisco, Francois D'Hooge, Arnaud Tiberghien, Conor S Barry, Philip Howard, Matthew K Higgins, Tristan J Vaughan, Ralph Minter, Mark Carrin

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway

人类 T 调节细胞中的 TNFR2 连接通过非经典 NF-κB 通路增强 IL2 诱导的细胞增殖

Jun Wang, Ricardo Ferreira, Wanhua Lu, Samatha Farrow, Kate Downes, Lutz Jermutus, Ralph Minter, Rafia S Al-Lamki, Jordan S Pober, John R Bradley