Ram Samudrala相关文献与解析，生知库 | 链接生命科学的每一步

Multiscale Analysis and Validation of Effective Drug Combinations Targeting Driver KRAS Mutations in Non-Small Cell Lung Cancer

针对非小细胞肺癌驱动基因 KRAS 突变的有效药物组合的多尺度分析与验证

期刊:International Journal of Molecular Sciences

doi:10.3390/ijms24020997

Liana Bruggemann, Zackary Falls, William Mangione, Stanley A Schwartz, Sebastiano Battaglia, Ravikumar Aalinkeel, Supriya D Mahajan, Ram Samudrala

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

蛋白模拟淀粉样蛋白抑制剂有效消除癌症相关的突变 p53 聚集并恢复肿瘤抑制功能

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-021-23985-1

L Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J Afzal, Andrew D Hami

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

一种合成小分子通过促进早期 U2AF2-RNA 复合物来阻止前 mRNA 剪接

期刊:Cell Chemical Biology

影响因子:6.6

doi:10.1016/j.chembiol.2021.02.007

Rakesh Chatrikhi, Callen F Feeney, Mary J Pulvino, Georgios Alachouzos, Andrew J MacRae, Zackary Falls, Sumit Rai, William W Brennessel, Jermaine L Jenkins, Matthew J Walter, Timothy A Graubert, Ram Samudrala, Melissa S Jurica, Alison J Frontier, Clara L Kielkopf

信号转导

发表日期：2021

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A fluorescence-based, gain-of-signal, live cell system to evaluate SARS-CoV-2 main protease inhibition

基于荧光的信号增益活细胞系统用于评估 SARS-CoV-2 主要蛋白酶抑制作用

期刊:Antiviral Research

影响因子:4.5

doi:10.1016/j.antiviral.2021.105183

Rama Dey-Rao, George R Smith, Uddhav Timilsina, Zackary Falls, Ram Samudrala, Spyridon Stavrou, Thomas Melendy

Caries induced cytokine network in the odontoblast layer of human teeth

人类牙齿成牙本质细胞层中龋病诱导的细胞因子网络

期刊:BMC Immunology

影响因子:2.9

doi:10.1186/1471-2172-12-9

Orapin V Horst, Jeremy A Horst, Ram Samudrala, Beverly A Dale

Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

铜绿假单胞菌利用环双 GMP 调节的粘附素来强化生物膜细胞外基质

期刊:Molecular Microbiology

影响因子:2.6

doi:10.1111/j.1365-2958.2009.06991.x

Bradley R Borlee, Aaron D Goldman, Keiji Murakami, Ram Samudrala, Daniel J Wozniak, Matthew R Parsek

The impact of nucleosome structure on CRISPR/Cas9 fidelity

核小体结构对 CRISPR/Cas9 保真度的影响

Multiscale Analysis and Validation of Effective Drug Combinations Targeting Driver KRAS Mutations in Non-Small Cell Lung Cancer

针对非小细胞肺癌驱动基因 KRAS 突变的有效药物组合的多尺度分析与验证

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

蛋白模拟淀粉样蛋白抑制剂有效消除癌症相关的突变 p53 聚集并恢复肿瘤抑制功能

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

一种合成小分子通过促进早期 U2AF2-RNA 复合物来阻止前 mRNA 剪接

A fluorescence-based, gain-of-signal, live cell system to evaluate SARS-CoV-2 main protease inhibition

基于荧光的信号增益活细胞系统用于评估 SARS-CoV-2 主要蛋白酶抑制作用

Caries induced cytokine network in the odontoblast layer of human teeth

人类牙齿成牙本质细胞层中龋病诱导的细胞因子网络

Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

铜绿假单胞菌利用环双 GMP 调节的粘附素来强化生物膜细胞外基质