日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Real-Time Binding Kinetics of Membrane Protein-Protein Interactions in a Membraneless Setting

无膜环境下膜蛋白-蛋白相互作用的实时结合动力学

Wang, Yazheng; Wu, Yalun; Mayse, Lauren A; Capucilli, Danny; Huang, Po-Jung J; Ramachandran, Sekar; Luikham, Soching; Ha, Jeung-Hoi; Loh, Stewart N; Wolfe, Aaron J; Movileanu, Liviu

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.

转导蛋白与磷酸二酯酶 6 之间的视觉信号复合物的结构

Gao Yang, Eskici Gözde, Ramachandran Sekar, Poitevin Frédéric, Seven Alpay Burak, Panova Ouliana, Skiniotis Georgios, Cerione Richard A

Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation

视紫红质-转导蛋白复合物的结构:对G蛋白激活的深入理解

Gao, Yang; Hu, Hongli; Ramachandran, Sekar; Erickson, Jon W; Cerione, Richard A; Skiniotis, Georgios

Gain-of-function screen of α-transducin identifies an essential phenylalanine residue necessary for full effector activation

α-转导蛋白的功能获得性筛选鉴定出一个对效应蛋白完全激活至关重要的苯丙氨酸残基。

Milano, Shawn K; Wang, Chenyue; Erickson, Jon W; Cerione, Richard A; Ramachandran, Sekar

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

具有 Gα 结合和激活基序的非 GPCR 蛋白激活 Gαi 的分子机制

de Opakua Alain Ibáñez, Parag-Sharma Kshitij, DiGiacomo Vincent, Merino Nekane, Leyme Anthony, Marivin Arthur, Villate Maider, Nguyen Lien T, de la Cruz-Morcillo Miguel Angel, Blanco-Canosa Juan B, Ramachandran Sekar, Baillie George S, Cerione Richard A, Blanco Francisco J, Garcia-Marcos Mikel

Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex

分离并表征具有信号活性的视紫红质-G蛋白复合物的结构-功能

Gao, Yang; Westfield, Gerwin; Erickson, Jon W; Cerione, Richard A; Skiniotis, Georgios; Ramachandran, Sekar

Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS

谷氨酰胺酶激活的机制基础:促进癌细胞谷氨酰胺代谢的关键酶

Li, Yunxing; Erickson, Jon W; Stalnecker, Clint A; Katt, William P; Huang, Qingqiu; Cerione, Richard A; Ramachandran, Sekar

Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity

小角X射线散射研究揭示了线粒体谷氨酰胺酶C的延伸柔性区域,并将寡聚状态与酶活性联系起来。

Møller, Magda; Nielsen, Søren S; Ramachandran, Sekar; Li, Yunxing; Tria, Giancarlo; Streicher, Werner; Petoukhov, Maxim V; Cerione, Richard A; Gillilan, Richard E; Vestergaard, Bente

A constitutively active Gα subunit provides insights into the mechanism of G protein activation

组成型活性Gα亚基为深入了解G蛋白激活机制提供了重要线索。

Singh, Garima; Ramachandran, Sekar; Cerione, Richard A