日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Microbiota-mediated induction of beige adipocytes in response to dietary cues.

微生物群介导的米色脂肪细胞对饮食信号的反应。

Tanoue Takeshi, Nagayama Manabu, Roochana Ayumi J A, Zimmerman Samuel, Ashenberg Orr, Jain Tanvi, Igarashi Ryo, Sasajima Satoshi, Takeshita Kozue, Hetherington Nicola, Okahashi Nobuyuki, Ueda Masahiro, Konishi Morichika, Nakayama Yoshiaki, Minoda Aki, Skelly Ashwin N, Minokoshi Yasuhiko, Pucci Nicholas, Mende Daniel R, Arita Makoto, Yamamoto Hironori, Watanabe Shunji, Miura Kouichi, Behie Scott W, Suda Wataru, Sato Toshiro, Atarashi Koji, Matsushita Mami, Kajimura Shingo, Plichta Damian R, Saito Masayuki, Xavier Ramnik J, Honda Kenya

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.

双向 CRISPR 筛选解码 GLIS3 依赖性纤维化细胞回路。

Pokatayev Vladislav, Jaiswal Alok, Shih Angela R, Segerstolpe à sa, Li Bihua, Creasey Elizabeth A, Zhao Yanhua, Lin Crystal, Murphy Shane, Chou Chih-Hung, Graham Daniel B, Xavier Ramnik J

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

人类遗传学指导着具有抗炎活性的 CARD9 抑制剂的发现。

Rush Jason S, Wertheimer Joshua D, Goldberg Steven D, Raymond Donald, Szuchnicki Mateusz, Baltus Andrew J, Branson Jeff, Stratton Christopher F, Patrick Aaron N, Steele Ruth, Adhikary Suraj, Del Rosario Amanda, Liu Annie, Gomersall Noah J, Chung Michael, Ranaghan Matthew J, Gu Xiebin, Brandt Marta, Cao Zhifang, Bebenek Adrian, Oliver Blayne A, Hoebe Kasper, Szewczuk Lawrence M, Venable Jennifer D, Graham Daniel B, Towne Jennifer, Xavier Ramnik J

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk

全基因组关联分析揭示了自身免疫性甲状腺功能减退症的自身免疫和甲状腺特异性因素,以及与癌症风险的负相关关系。

Reeve, Mary Pat; Kanai, Masahiro; Graham, Daniel B; Karjalainen, Juha; Luo, Shuang; Kolosov, Nikita; Adams, Cameron; Ritari, Jarmo; Karczewski, Konrad J; Kiiskinen, Tuomo; Jiang, Yu; Fuller, Zachary; Mehtonen, Juha; Kurki, Mitja I; Khan, Zia; Partanen, Jukka; McCarthy, Mark I; Artomov, Mykyta; Palotie, Aarno; Tuomi, Tiinamaija; Pirinen, Matti; Kero, Jukka; Xavier, Ramnik J; Daly, Mark J; Ripatti, Samuli

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis

多模态皮肤图谱揭示了与特应性皮炎中角质化紊乱和特定T细胞扩增相关的多细胞免疫基质群落

Fiskin, Evgenij; Eraslan, Gökcen; Alora-Palli, Maria B; Jain, Tanvi; Leyva-Castillo, Juan Manuel; Kim, Sean; Choe, Heather; Lareau, Caleb A; Lau, Helena; Finan, Emily P; Teixeira-Soldano, Isabella; LaBere, Brenna; Chu, Anne; Woods, Brian; Chou, Janet; Slyper, Michal; Waldman, Julia; Islam, Sabina; Schneider, Lynda; Phipatanakul, Wanda; Platt, Craig; Rozenblatt-Rosen, Orit; Delorey, Toni M; Ashenberg, Orr; Deguine, Jacques; Smith, Gideon P; Geha, Raif S; Regev, Aviv; Xavier, Ramnik J

Population and single-cell analyses reveal immune cell-specific expression profiles associated with Alzheimer's disease risk

群体和单细胞分析揭示了与阿尔茨海默病风险相关的免疫细胞特异性表达谱。

Lindbohm, Joni V; Stražar, Martin; Lee, Hang-Mao; Ashenberg, Orr; Mars, Nina; Sipilä, Pyry N; Ripatti, Samuli; Graham, Dan; Kivimäki, Mika; Xavier, Ramnik J

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.

空间转录组学揭示了间质性肺疾病中异常上皮细胞和促纤维化成纤维细胞的改变群落和驱动因素。

Jaiswal Alok, Kooistra Tristan, Pokatayev Vladislav, Bastos Hélder N, Santos Rita F, Sarraf Tresa R, Segerstolpe à sa, Lin Crystal, Amir-Zilberstein Liat, Twardus Shaina, Shannon Kevin, Murphy Shane P, Knipe Rachel, Ganzleben Ingo K, Black Katharine E, Delorey Toni M, Graham Daniel B, Hung Yin P, Hariri Lida P, Deguine Jacques, Carvalho Agostinho, Medoff Benjamin D, Xavier Ramnik J

Identifying microbial protease allergens through protein language model-guided homology.

通过蛋白质语言模型指导的同源性鉴定微生物蛋白酶过敏原。

Thurimella Kumar, Wu Elena, Li Chenhao, Graham Daniel B, Owens Róisín M, Plichta Damian R, Sokol Caroline L, Xavier Ramnik J, Bacallado Sergio

Hidden immune memory niches in inflammatory skin diseases

炎症性皮肤病中隐藏的免疫记忆位点

Steele, Lloyd; Foster, April R; Roberts, Kenny; Admane, Chloe; Birk, Sebastian; Mazin, Pavel V; Akbarnejad, Amir; Tudor, Catherine; Rumney, Benjamin; Chan, Hon Man; Olabi, Bayanne; Jiang, Treasa; Rowe, Victoria; Baudry, David; Hale, Christine; Winheim, Elena; Farr, Elias; McWilliam, Joe; Gambardella, Laure; Chakala, Keerthi Priya; Gopee, Nusayhah H; Binkevich, Aljes; Predeus, Alexander; Prete, Martin; Vahidi, Amirhossein; O'Toole, Edel A; Basurto-Lozada, Daniela; Horsfall, David; Stephenson, Emily; Shanmugiah, Vijaya Baskar Mahalingam; Geha, Raif S; Xavier, Ramnik J; Smith, Catherine; Mahil, Satveer; Lotfollahi, Mohammad; Haniffa, Muzlifah

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense

2型细胞因子作用于肠道感觉神经元,调节神经肽驱动的宿主防御机制。

Barilla, Rocky M; Berard, Clara; Sun, Linyu; Sandhu, Sumiti; Zaghouani, Sarah; Iyer, Krishna S; Altun, Gizem; Su, Chien-Wen; Deguine, Jacques; Singh, Vasundhara; Hou, Yu; Kusumakar, Kanupriya; Rutlin, Michael L; Rao, Meenakshi; Zaghouani, Habib; Shi, Hai Ning; Xavier, Ramnik J; Kuchroo, Vijay K