日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53

乙酰化靶向嵌合体使肿瘤抑制因子 p53 乙酰化

Md Kabir, Ning Sun, Xiaoping Hu, Tiphaine C Martin, Jingjie Yi, Yue Zhong, Yan Xiong, H Ümit Kaniskan, Wei Gu, Ramon Parsons, Jian Jin

In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity

体内 RNA 测序和 ChIP 测序分析表明,p53 的 C 末端在赋予组织特异性放射敏感性方面起着必需的作用

Lois Resnick-Silverman, Royce Zhou, Moray J Campbell, Ian Leibling, Ramon Parsons, James J Manfredi

Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma

PBAF缺陷型黑色素瘤中BAF占有率和转录因子动态的改变

Saul Carcamo ,Christie B Nguyen ,Elena Grossi ,Dan Filipescu ,Aktan Alpsoy ,Alisha Dhiman ,Dan Sun ,Sonali Narang ,Jochen Imig ,Tiphaine C Martin ,Ramon Parsons ,Iannis Aifantis ,Aristotelis Tsirigos ,Julio A Aguirre-Ghiso ,Emily C Dykhuizen ,Dan Hasson ,Emily Bernstein

Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma

PBRM1 缺失会改变启动子组蛋白修饰并激活 ALDH1A1 以驱动肾细胞癌

David A Schoenfeld #, Royce Zhou #, Sakellarios Zairis, William Su, Nicole Steinbach, Deepti Mathur, Ankita Bansal, Alexis L Zachem, Bertilia Tavarez, Dan Hasson, Emily Bernstein, Raul Rabadan, Ramon Parsons

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B

AKT降解通过使Aurora激酶B不稳定,选择性地抑制具有野生型KRAS和BRAF的PI3K/PTEN通路突变型癌症的生长。

Jia Xu # ,Xufen Yu # ,Tiphaine C Martin ,Ankita Bansal ,Kakit Cheung ,Abigail Lubin ,Elias Stratikopoulos ,Kaitlyn M Cahuzac ,Li Wang ,Ling Xie ,Royce Zhou ,Yudao Shen ,Xuewei Wu ,Shen Yao ,Ruifang Qiao ,Poulikos I Poulikakos ,Xian Chen ,Jing Liu ,Jian Jin ,Ramon Parsons

NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer

NOTCH 和 EZH2 协作抑制乳腺癌中的 PTEN 表达

Kyrie Pappas, Tiphaine C Martin, Andrew L Wolfe, Christie B Nguyen, Tao Su, Jian Jin, Hanina Hibshoosh, Ramon Parsons

Discovery of a first-in-class EZH2 selective degrader

发现首创的 EZH2 选择性降解剂

Anqi Ma #, Elias Stratikopoulos #, Kwang-Su Park #, Jieli Wei, Tiphaine C Martin, Xiaobao Yang, Megan Schwarz, Violetta Leshchenko, Alexander Rialdi, Brandon Dale, Alessandro Lagana, Ernesto Guccione, Samir Parekh, Ramon Parsons, Jian Jin

Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of ex vivo Expanded Human Hematopoietic Stem Cells

有限的线粒体活性与 CD34、CD90 和 EPCR 的强烈表达决定了体外扩增的人类造血干细胞的功能适应性

Luena Papa, Mansour Djedaini, Tiphaine C Martin, Mahtab Zangui, Kristin G Beaumont, Robert Sebra, Ramon Parsons, Christoph Schaniel, Ronald Hoffman

PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice

PIK3CA 和 p53 突变促进小鼠 4NQO 引发的头颈部肿瘤进展和转移

Darío García-Carracedo, Yi Cai, Wanglong Qiu, Kiyoshi Saeki, Richard A Friedman, Andrew Lee, Yinglu Li, Elizabeth M Goldberg, Elias E Stratikopoulos, Ramon Parsons, Chao Lu, Argiris Efstratiadis, Elizabeth M Philipone, Angela J Yoon, Gloria H Su

Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents

外源性雌激素引起的小鼠 ER+/PIK3CAH1047R 乳腺癌异质性地依赖于雌激素,并通过 BH3 和 PI3K 药物发生 BIM 依赖性细胞凋亡

Elias E Stratikopoulos, Nicole Kiess, Matthias Szabolcs, Sarah Pegno, Cheung Kakit, Xuewei Wu, Poulikos I Poulikakos, Pamela Cheung, Hank Schmidt, Ramon Parsons