Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake
系统性抑制嘌呤从头生物合成可防止体重增加,并通过增加产热作用和减少食物摄入来改善代谢健康
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doi:10.1101/2024.10.28.620705
Jacob W Myers, Woo Yong Park, Alexander M Eddie, Abhijit B Shinde, Praveena Prasad, Alexandria C Murphy, Michael Z Leonard, Julia A Pinette, Jessica J Rampy, Claudia Montufar, Zayedali Shaikh, Tara T Hickman, Garrett N Reynolds, Nathan C Winn, Louise Lantier, Sun H Peck, Katie C Coate, Roland W Stei