日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

克服SARS-CoV-2 nsp5蛋白酶中尼尔马特雷韦耐药机制的策略

Neilsen, Grace; Lan, Shuiyun; Slack, Ryan L; Lorson, Zachary C; Emanuelli Castaner, Andres; Lee, Rachel; Edwards, Kristin G; Zhang, Huanchun; Lee, Jasper; Cantara, William A; Cilento, Maria E; Zhang, Hongwang; De, Ramyani; Amblard, Franck; Tedbury, Philip R; Kirby, Karen A; Schinazi, Raymond F; Sarafianos, Stefan G

1'-Cyanocytidine-5'-isobutyryl is a potent SARS-CoV-2 inhibitor in culture and infected Syrian hamsters

1'-氰胞苷-5'-异丁酰基在体外培养和感染叙利亚仓鼠中均表现出对SARS-CoV-2的强效抑制作用。

Amblard, Franck; Kasthuri, Mahesh; LeCher, Julia C; Tao, Sijia; De, Ramyani; Abdelnabi, Rana; Marko, Ingrid; Zhou, Longhu; Li, Chengwei; Shi, Junxing; Goh, Shu Ling; Downs-Bowen, Jessica; Bassit, Leda; Hurwitz, Selwyn; Zandi, Keivan; McBrayer, Tamara; Weynand, Birgit; Johnson, Kenneth A; Neyts, Johan; Schinazi, Raymond F

Combating yellow fever virus with 7-deaza-7-fluoro-2'-C-methyladenosine

用7-脱氮-7-氟-2'-C-甲基腺苷对抗黄热病毒

LeCher, Julia C; Costa, Vivian Vasconcelos; Rust, Lauren N; Bassit, Leda C; Patel, Dharmeshkumar; Rezaei, Sahar; Moua, Justin; Santos, Felipe Rocha da Silva; Goncalves, Matheus Rodrigues; Queroz-Junior, Celso Martins; Marim, Fernanda Martins; Zhou, Longhu; Lee, Sujin; McBrayer, Tamara; De, Ramyani; Azadi, Niloufar; Salman, Mohammad; Zandi, Keivan; Amblard, Franck; Burwitz, Benjamin; Teixeira, Mauro M; Schinazi, Raymond F

Discovery of broad-spectrum antivirals targeting viral proteases using in silico structural modeling and cellular analysis

利用计算机结构建模和细胞分析发现靶向病毒蛋白酶的广谱抗病毒药物

Patel, Dharmeshkumar; De, Ramyani; Azadi, Niloufar; Lee, Sujin; Shooter, Savannah; Amichai, Sarah; Zhou, Shaoman; Monroe, Danielle; Mahanke, Cameron; McBrayer, Tamara R; Muczynski, Michael; Al-Homoudi, Abdullah; Engel, Joseph; Bochkov, Yury A; Gern, James E; Kovari, Ladislau C; Amblard, Franck; Schinazi, Raymond F

Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.

冠状病毒3C样蛋白酶新型肽模拟抑制剂的合成及生物学评价

Amblard Franck, LeCher Julia C, De Ramyani, Zhou Shaoman, Liu Peng, Goh Shu Ling, Tao Sijia, Patel Dharmeshkumar, Downs-Bowen Jessica, Zandi Keivan, Zhang Huanchun, Chaudhry Gitika, McBrayer Tamara, Muczynski Michael, Al-Homoudi Abdullah, Engel Joseph, Lan Shuiyun, Sarafianos Stefan G, Kovari Ladislau C, Schinazi Raymond F

Cannabinoid-Inspired Inhibitors of the SARS-CoV-2 Coronavirus 2'-O-Methyltransferase (2'-O-MTase) Non-Structural Protein (Nsp10-16)

受大麻素启发的SARS-CoV-2冠状病毒2'-O-甲基转移酶(2'-O-MTase)非结构蛋白(Nsp10-16)抑制剂

Benjamin, Menny M; Hanna, George S; Dickinson, Cody F; Choo, Yeun-Mun; Wang, Xiaojuan; Downs-Bowen, Jessica A; De, Ramyani; McBrayer, Tamara R; Schinazi, Raymond F; Nielson, Sarah E; Hevel, Joan M; Pandey, Pankaj; Doerksen, Robert J; Townsend, Danyelle M; Zhang, Jie; Ye, Zhiwei; Wyer, Scott; Bialousow, Lucas; Hamann, Mark T

Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV-2 2'-O-Methyltransferase

利用信息学和计算方法发现和优化天然产物启发的SARS-CoV-2 2'-O-甲基转移酶抑制剂

Hanna, George S; Benjamin, Menny M; Choo, Yeun-Mun; De, Ramyani; Schinazi, Raymond F; Nielson, Sarah E; Hevel, Joan M; Hamann, Mark T

Development of robust antiviral assays using relevant apical-out human airway organoids

使用相关的顶端向外人类气道类器官开发强大的抗病毒检测方法

Ji-Hoon Lee, Julia C LeCher, Eric Parigoris, Noriyuki Shinagawa, Jason Sentosa, Candela Manfredi, Shu Ling Goh, Ramyani De, Sijia Tao, Keivan Zandi, Franck Amblard, Eric J Sorscher, Jason R Spence, Rabindra Tirouvanziam, Raymond F Schinazi, Shuichi Takayama

Rhinoviruses A and C elicit long-lasting antibody responses with limited cross-neutralization

鼻病毒A和C可诱导产生持久的抗体反应,但交叉中和作用有限。

Bochkov, Yury A; Devries, Mark; Tetreault, Kaitlin; Gangnon, Ronald; Lee, Sujin; Bacharier, Leonard B; Busse, William W; Camargo, Carlos A; Choi, Timothy; Cohen, Robyn; De, Ramyani; DeMuri, Gregory P; Fitzpatrick, Anne M; Gergen, Peter J; Grindle, Kristine; Gruchalla, Rebecca; Hartert, Tina; Hasegawa, Kohei; Khurana Hershey, Gurjit K; Holt, Patrick; Homil, Kiara; Jartti, Tuomas; Kattan, Meyer; Kercsmar, Carolyn; Kim, Haejin; Laing, Ingrid A; Le Souëf, Peter N; Liu, Andrew H; Mauger, David T; Pappas, Tressa; Patel, Shilpa J; Phipatanakul, Wanda; Pongracic, Jacqueline; Seroogy, Christine; Sly, Peter D; Tisler, Christopher; Wald, Ellen R; Wood, Robert; Lemanske, Robert F Jr; Jackson, Daniel J; Gern, James E

Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice

发现一种2'-氟-2'-溴尿苷磷酰胺前药在体外培养和小鼠体内均表现出抗黄热病毒活性

LeCher, Julia C; Zandi, Keivan; Costa, Vivian Vasconcelos; Amblard, Franck; Tao, Sijia; Patel, Dharmeshkumar; Lee, Sujin; da Silva Santos, Felipe Rocha; Goncalves, Matheus Rodrigues; Queroz-Junior, Celso Martins; Marim, Fernanda Martins; Musall, Katie; Goh, Shu Ling; McBrayer, Tamara; Downs-Bowen, Jessica; De, Ramyani; Azadi, Niloufar; Kohler, James; Teixeira, Mauro Martins; Schinazi, Raymond F