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FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

FGF21介导的SIRT1上调通过FOXO3去乙酰化促进PINK1/Parkin依赖性线粒体自噬，从而延缓椎间盘退变。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.70449

Wu, Zuo-Long; Ran, Rui; Xie, Qi-Qi; Zhang, Cong; Chen, Ya-Jun; Cheng, Peng; Wang, Ke-Ping; Zhang, Hai-Hong

Single-cell and multi-omics analyses identify CAMP-associated neutrophil remodeling during radiochemotherapy in cervical cancer

单细胞和多组学分析揭示宫颈癌放化疗期间CAMP相关的嗜中性粒细胞重塑

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2026.1773562

Li, Wenqian; Ran, Rui; Li, Jing

Depressive symptoms mediate the associations between air pollution exposure and anemia risk: a nationwide longitudinal study in China

抑郁症状在空气污染暴露与贫血风险之间起中介作用：一项中国全国性纵向研究

期刊:BMC Public Health

影响因子:3.6

doi:10.1186/s12889-026-26587-y

Kou, Yanqi; Huang, Zhe; Ye, Shicai; Yu, Sitong; Yin, Wanyi; Yang, Junyi; Zhong, Yanxuan; Qin, Ling; Yang, Ke; Huang, Yujie; Zhang, Qing; Ran, Rui; Huang, Huiqi; Jiang, Wantong; Yang, Yuping

Focus on P2X7R in microglia: its mechanism of action and therapeutic prospects in various neuropathic pain models

聚焦小胶质细胞中的P2X7R：其作用机制及在多种神经性疼痛模型中的治疗前景

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2025.1555732

Zhang, Kai; Ran, Rui; Zhang, Cheng-Jun; Wang, Linna; Zhang, Hai-Hong

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes

时间疗法与椎间盘退变：了解昼夜节律在退变过程中的作用

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2025.1586193

Zhang, Cong; Zhang, Rende; Zhao, Guanghai; Wu, Zuolong; Song, Wei; Ran, Rui; Zhou, Kaisheng; Zhang, Haihong

发表日期：2025

文献求助收藏

A metabolic fingerprint of ovarian cancer: a novel diagnostic strategy employing plasma EV-based metabolomics and machine learning algorithms.

卵巢癌的代谢指纹：一种采用基于血浆细胞外囊泡的代谢组学和机器学习算法的新型诊断策略

期刊:Journal of Ovarian Research

影响因子:4.2

doi:10.1186/s13048-025-01590-w

Long Fei, Pu XingYu, Wang Xin, Ma DongXue, Gao ShanHu, Shi Jun, Zhong XiaoCui, Ran Rui, Wang LianLian, Chen Zhu, Yang Yang, Cannon Richard D, Han Ting-Li

Large-scale prospective serum metabolomic profiling reveals candidate predictive biomarkers for suspected preeclampsia patients

大规模前瞻性血清代谢组学分析揭示了疑似先兆子痫患者的候选预测生物标志物

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-87905-9

Cao, Yan; Meng, Lanlan; Wang, Yifei; Zhao, Shenglong; Zheng, Yuanyuan; Ran, Rui; Du, Jie; Wu, Hongqiang; Han, Jiaqi; Xu, Zhengwen; Lu, Yifan; Liu, Lin; Chen, Lu; Wang, Jing; Li, Youran; Zhai, Yanhong; Sun, Zhi; Cao, Zheng

代谢

发表日期：2025

文献求助收藏

Novel marker genes and small molecule drugs for radiotherapy resistance in cervical cancer identified based on single-cell multi-omics analysis

基于单细胞多组学分析鉴定出宫颈癌放射治疗耐药的新型标志基因和小分子药物

期刊:Discover Oncology

影响因子:2.9

doi:10.1007/s12672-025-02532-0

Liu, Yang; Pan, Xin; Zhang, Xu; Tan, Bo; Ran, Rui; Liu, Li; Yang, Lin; Wang, Zhiliang

Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters

基于铁蛋白纳米颗粒的尼帕病毒糖蛋白疫苗在小鼠和仓鼠中引发强大的保护性免疫反应

期刊:Virologica Sinica

影响因子:4.3

doi:10.1016/j.virs.2024.09.005

Shaohong Chen, Xinghai Zhang, Yanfeng Yao, Shengdong Wang, Kangyin Li, Baoyue Zhang, Tianxi Ye, Li Chen, Yan Wu, Entao Li, Bichao Xu, Pei Zhang, Xia Chuai, Yong Ran, Rui Gong, Huajun Zhang, Sandra Chiu

免疫

发表日期：2024

文献求助收藏

Monochorionic-twin-on-a-chip for investigating fetal organ growth and metabolism

用于研究胎儿器官生长和代谢的单绒毛膜双胎芯片

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

FGF21介导的SIRT1上调通过FOXO3去乙酰化促进PINK1/Parkin依赖性线粒体自噬，从而延缓椎间盘退变。

Single-cell and multi-omics analyses identify CAMP-associated neutrophil remodeling during radiochemotherapy in cervical cancer

单细胞和多组学分析揭示宫颈癌放化疗期间CAMP相关的嗜中性粒细胞重塑

Depressive symptoms mediate the associations between air pollution exposure and anemia risk: a nationwide longitudinal study in China

抑郁症状在空气污染暴露与贫血风险之间起中介作用：一项中国全国性纵向研究

Focus on P2X7R in microglia: its mechanism of action and therapeutic prospects in various neuropathic pain models

聚焦小胶质细胞中的P2X7R：其作用机制及在多种神经性疼痛模型中的治疗前景

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes

时间疗法与椎间盘退变：了解昼夜节律在退变过程中的作用

A metabolic fingerprint of ovarian cancer: a novel diagnostic strategy employing plasma EV-based metabolomics and machine learning algorithms.

卵巢癌的代谢指纹：一种采用基于血浆细胞外囊泡的代谢组学和机器学习算法的新型诊断策略

Large-scale prospective serum metabolomic profiling reveals candidate predictive biomarkers for suspected preeclampsia patients

大规模前瞻性血清代谢组学分析揭示了疑似先兆子痫患者的候选预测生物标志物

Novel marker genes and small molecule drugs for radiotherapy resistance in cervical cancer identified based on single-cell multi-omics analysis

基于单细胞多组学分析鉴定出宫颈癌放射治疗耐药的新型标志基因和小分子药物

Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters

基于铁蛋白纳米颗粒的尼帕病毒糖蛋白疫苗在小鼠和仓鼠中引发强大的保护性免疫反应