日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

人类遗传学指导着具有抗炎活性的 CARD9 抑制剂的发现。

Rush Jason S, Wertheimer Joshua D, Goldberg Steven D, Raymond Donald, Szuchnicki Mateusz, Baltus Andrew J, Branson Jeff, Stratton Christopher F, Patrick Aaron N, Steele Ruth, Adhikary Suraj, Del Rosario Amanda, Liu Annie, Gomersall Noah J, Chung Michael, Ranaghan Matthew J, Gu Xiebin, Brandt Marta, Cao Zhifang, Bebenek Adrian, Oliver Blayne A, Hoebe Kasper, Szewczuk Lawrence M, Venable Jennifer D, Graham Daniel B, Towne Jennifer, Xavier Ramnik J

Characterization of RNA using mass photometry: Method and technical perspectives

利用质谱光度法对RNA进行表征:方法和技术展望

Barnes, Lauren F; Watt, Brenda; Jalal, Salma; Karunanithy, Gogulan; Ranaghan, Matthew J; Rood, Josephine; Wang, Hanliu L

High-Throughput Screening Tool to Identify Small Molecule Inhibitors of Telomerase

用于鉴定端粒酶小分子抑制剂的高通量筛选工具

Aquilanti, Elisa; Barkho, Sulyman; Bozinov, Vincent; Kageler, Lauren; Garrity-Janger, Max; Mesleh, Michael F; Horner, Steven; Ranaghan, Matthew J; Meyerson, Matthew

Northern Ireland ovarian cancer prehabilitation project

北爱尔兰卵巢癌预防康复项目

McMullan, Josh Courtney; Lee, Davinia; Ranaghan, Lisa; Gowan, Nicola; McWilliams, Lisa; McGreevy, Bernie; O'Hagan, Danielle; Nugent, Brenda; Dobbs, Stephen

Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

通过改变构象状态对 PPM1D 丝氨酸/苏氨酸磷酸酶进行变构抑制

Peter G Miller #, Murugappan Sathappa #, Jamie A Moroco #, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S Sperling, Christopher J Gibson, Josephine Kahn, Cyrus Jin, Matthew Ranaghan, Alisha Caliman

Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

PDE3A-SLFN12复合物的结构揭示了SLFN12 RNase激活的必要条件

Colin W Garvie #,Xiaoyun Wu #,Malvina Papanastasiou,Sooncheol Lee,James Fuller,Gavin R Schnitzler,Steven W Horner,Andrew Baker,Terry Zhang,James P Mullahoo,Lindsay Westlake,Stephanie H Hoyt,Marcus Toetzl,Matthew J Ranaghan,Luc de Waal,Joseph McGaunn,Bethany Kaplan,Federica Piccioni,Xiaoping Yang,Martin Lange,Adrian Tersteegen,Donald Raymond,Timothy A Lewis,Steven A Carr,Andrew D Cherniack,Christopher T Lemke,Matthew Meyerson,Heidi Greulich

Molecular basis for substrate recruitment to the PRMT5 methylosome

PRMT5 甲基化酶体底物募集的分子基础

Kathleen M Mulvaney, Christa Blomquist, Nischal Acharya, Ruitong Li, Matthew J Ranaghan, Meghan O'Keefe, Diego J Rodriguez, Michael J Young, Devishi Kesar, Debjani Pal, Matthew Stokes, Alissa J Nelson, Sidharth S Jain, Annan Yang, Zachary Mullin-Bernstein, Josie Columbus, Fazli K Bozal, Adam Skepner

Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction

发现首创的 PRMT5-底物适配器相互作用抑制剂

David C McKinney, Brian J McMillan, Matthew J Ranaghan, Jamie A Moroco, Merissa Brousseau, Zachary Mullin-Bernstein, Meghan O'Keefe, Patrick McCarren, Michael F Mesleh, Kathleen M Mulvaney, Foxy Robinson, Ritu Singh, Besnik Bajrami, Florence F Wagner, Robert Hilgraf, Martin J Drysdale, Arthur J Camp

Assessing optimal: inequalities in codon optimization algorithms

评估最优性:密码子优化算法中的不等式

Ranaghan, Matthew J; Li, Jeffrey J; Laprise, Dylan M; Garvie, Colin W

Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation

调控单萜合成酶的反应活性以指导区域选择性产物羟基化

Leferink, Nicole G H; Ranaghan, Kara E; Battye, Jaime; Johannissen, Linus O; Hay, Sam; van der Kamp, Marc W; Mulholland, Adrian J; Scrutton, Nigel S