日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Midterm outcomes of aortic valve replacement using a rapid-deployment valve for aortic stenosis: TRANSFORM trial

使用快速部署瓣膜进行主动脉瓣置换术治疗主动脉瓣狭窄的中期结果:TRANSFORM试验

Malaisrie, S Chris; Mumtaz, Mubashir A; Barnhart, Glenn R; Chitwood, Randolph; Ryan, William H; Accola, Kevin D; Patel, Himanshu J; Woo, Y Joseph; Dewey, Todd M; Koulogiannis, Konstantinos; Dorsey, Michael P; Grossi, Eugene A

An optimized temporally controlled Gal4 system in Drosophila reveals degeneration caused by adult-onset neuronal Vps13D knockdown

果蝇中优化的时间控制 Gal4 系统揭示了成年期神经元 Vps13D 敲低引起的退化

Emily Rozich, Lynsey K Randolph, Ryan Insolera

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

HDAC6 对 Miro1 的去乙酰化作用阻断了线粒体运输,并介导了轴突生长抑制。

Ashley L Kalinski # ,Amar N Kar # ,John Craver ,Andrew P Tosolini ,James N Sleigh ,Seung Joon Lee ,Alicia Hawthorne ,Paul Brito-Vargas ,Sharmina Miller-Randolph ,Ryan Passino ,Liang Shi ,Victor S C Wong ,Cristina Picci ,Deanna S Smith ,Dianna E Willis ,Leif A Havton ,Giampietro Schiavo ,Roman J Giger ,Brett Langley ,Jeffery L Twiss

Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles

皮肤利什曼病局部治疗:苯并硼氧烷类化合物的皮肤药代动力学先导化合物优化

Van Bocxlaer, Katrien; Gaukel, Eric; Hauser, Deirdre; Park, Seong Hee; Schock, Sara; Yardley, Vanessa; Randolph, Ryan; Plattner, Jacob J; Merchant, Tejal; Croft, Simon L; Jacobs, Robert T; Wring, Stephen A

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate

在基于生理的药代动力学模型中模拟富马酸替诺福韦二吡呋酯的肠道转运体和酶活性

Moss, Darren M; Domanico, Paul; Watkins, Melynda; Park, Seonghee; Randolph, Ryan; Wring, Steve; Rajoli, Rajith Kumar Reddy; Hobson, James; Rannard, Steve; Siccardi, Marco; Owen, Andrew

Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis

SCY-078(一种首创的口服活性抗真菌葡聚糖合成抑制剂)在播散性念珠菌病小鼠模型中的临床前药代动力学和药效学靶点研究

Wring, Stephen A; Randolph, Ryan; Park, SeongHee; Abruzzo, George; Chen, Qing; Flattery, Amy; Garrett, Graig; Peel, Michael; Outcalt, Russell; Powell, Kendall; Trucksis, Michelle; Angulo, David; Borroto-Esoda, Katyna

Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate.

开发一种新型制剂,以提高富马酸替诺福韦酯的临床前生物利用度

Watkins Melynda E, Wring Steve, Randolph Ryan, Park Seonghee, Powell Kendall, Lutz Lissa, Nowakowski Michelle, Ramabhadran Ram, Domanico Paul L

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

利用游离靶组织暴露量作为基于处置原理的苯并硼氧杂环化合物先导化合物优化方法,研究其在治疗第二阶段人类非洲锥虫病中的药代动力学和药效学。

Wring, Stephen; Gaukel, Eric; Nare, Bakela; Jacobs, Robert; Beaudet, Beth; Bowling, Tana; Mercer, Luke; Bacchi, Cyrus; Yarlett, Nigel; Randolph, Ryan; Parham, Robin; Rewerts, Cindy; Platner, Jacob; Don, Robert

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

SCYX-7158,一种口服有效的苯并硼氧杂环化合物,用于治疗2期人类非洲锥虫病

Jacobs, Robert T; Nare, Bakela; Wring, Stephen A; Orr, Matthew D; Chen, Daitao; Sligar, Jessica M; Jenks, Matthew X; Noe, Robert A; Bowling, Tana S; Mercer, Luke T; Rewerts, Cindy; Gaukel, Eric; Owens, Jennifer; Parham, Robin; Randolph, Ryan; Beaudet, Beth; Bacchi, Cyrus J; Yarlett, Nigel; Plattner, Jacob J; Freund, Yvonne; Ding, Charles; Akama, Tsutomu; Zhang, Y-K; Brun, Reto; Kaiser, Marcel; Scandale, Ivan; Don, Robert