日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

CDK2抑制剂BLU-222通过诱导p21/p27与CDK4/6抑制剂协同作用,治疗耐药性乳腺癌。

Luo, Linjie; Wang, Yan; Bui, Tuyen; Jiang, Xiaoting; Chen, Mei-Kuang; Rao, Xiayu; Mohammadhosseinpour, Sepideh; Li, Mi; Kim, Serena; Kim, Rachel Y; Kamaliasl, Saba; Ulizio, Carmen W; Tsavachidis, Spyros; Navarro-Yepes, Juliana; Kettner, Nicole M; Wingate, Hannah; Meric-Bernstam, Funda; Hunt, Kelly K; Wang, Jing; Faia, Kerrie; Keyomarsi, Khandan

Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer.

单细胞 RNA 测序可识别预测 HR+/HER2-转移性乳腺癌患者 CDK4/6 抑制剂治疗后期进展的分子生物标志物

Luo Linjie, Yang Peng, Mastoraki Sofia, Rao Xiayu, Wang Yan, Kettner Nicole M, Raghavendra Akshara Singareeka, Tripathy Debasish, Damodaran Senthil, Hunt Kelly K, Wang Jing, Li Ziyi, Keyomarsi Khandan

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer.

IL-6 预测 CDK4/6 抑制剂耐药性,确定 STAT3 为 HR+/HER2 阴性转移性乳腺癌的靶点

Kettner Nicole M, Bui Tuyen N, Navarro-Yepes Juliana, Ghotbaldini Sanaz, Quintela Bethanie, Luo Catherine K, Lam Nghi, Rao Xiayu, Raghavendra Akshara Singareeka, Wang Yan, Azizian Nancy, Kris Eckols T, Kasembeli Moses Makokha, Evans Kurt, Yi Min, Wingate Hannah, Wang Jing, Sahin Aysegul A, Meric-Bernstam Funda, Hunt Kelly K, Damodaran Senthil, Tweardy David J, Tripathy Debu, Keyomarsi Khandan

Immune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer

原发肿瘤的免疫浸润与口腔癌淋巴结转移伴结外扩散患者的临床预后相关。

Michikawa, Chieko; Gleber-Netto, Frederico O; Pickering, Curtis R; Rao, Xiayu; Wang, Jing; Sikora, Andrew G; Myers, Jeffrey N; Frederick, Mitchell J

Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade

肿瘤相关神经诱发的炎症会促进癌症患者对PD-1抑制剂治疗产生耐药性,而白细胞介素-6阻断剂可以靶向治疗这种耐药性。

Baruch, Erez N; Nagarajan, Priyadahrshini; Gleber-Netto, Frederico O; Rao, Xiayu; Xie, Tongxin; Akhter, Shamima; Adewale, Adebayo; Shajedul, Islam; Mattson, Brandi J; Ferrarotto, Renata; Wong, Michael K; Davies, Michael A; Jindal, Sonali; Basu, Sreyashi; Harwood, Catherine; Leigh, Irene; Ajami, Nadim; Futreal, Andrew; Castillo, Micah; Gunaratne, Preethi; Goepfert, Ryan P; Khushalani, Nikhil; Wang, Jing; Watowich, Stephanie; Calin, George A; Migden, Michael R; Vermeer, Paola; D'Silva, Nisha; Yaniv, Dan; Burks, Jared K; Gomez, Javier; Dougherty, Patrick M; Tsai, Kenneth Y; Allison, James P; Sharma, Padmanee; Wargo, Jennifer; Myers, Jeffrey N; Gross, Neil D; Amit, Moran

LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers

低分子量细胞周期蛋白E及其新型催化伴侣CDK5是唾液腺癌的治疗靶点和预后生物标志物。

Lulla, Amriti R; Akli, Said; Karakas, Cansu; Ha, Min Jin; Fowlkes, Natalie W; Mitani, Yoshitsugu; Bui, Tuyen; Wang, Jing; Rao, Xiayu; Hunt, Kelly K; Meijer, Laurent; El-Naggar, Adel K; Keyomarsi, Khandan

Loss of p53 drives neuron reprogramming in head and neck cancer

p53 缺失驱动头颈癌中的神经元重编程

Amit, Moran; Takahashi, Hideaki; Dragomir, Mihnea Paul; Lindemann, Antje; Gleber-Netto, Frederico O; Pickering, Curtis R; Anfossi, Simone; Osman, Abdullah A; Cai, Yu; Wang, Rong; Knutsen, Erik; Shimizu, Masayoshi; Ivan, Cristina; Rao, Xiayu; Wang, Jing; Silverman, Deborah A; Tam, Samantha; Zhao, Mei; Caulin, Carlos; Zinger, Assaf; Tasciotti, Ennio; Dougherty, Patrick M; El-Naggar, Adel; Calin, George A; Myers, Jeffrey N

Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer

在帕博西尼耐药的ER阳性乳腺癌中,STAT3和DNA修复的联合抑制

Kettner, Nicole M; Vijayaraghavan, Smruthi; Durak, Merih Guray; Bui, Tuyen; Kohansal, Mehrnoosh; Ha, Min Jin; Liu, Bin; Rao, Xiayu; Wang, Jing; Yi, Min; Carey, Jason P W; Chen, Xian; Eckols, T Kris; Raghavendra, Akshara S; Ibrahim, Nuhad K; Karuturi, Meghan Sri; Watowich, Stephanie S; Sahin, Aysegul; Tweardy, David J; Hunt, Kelly K; Tripathy, Debu; Keyomarsi, Khandan

Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions

利用游离DNA进行全外显子组测序以早期诊断肺癌:一项区分CT检测到的良恶性肺部病变的初步研究

Tailor, Tina D; Rao, Xiayu; Campa, Michael J; Wang, Jing; Gregory, Simon G; Patz, Edward F Jr

High-Risk TP53 Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma

高危TP53突变与口腔鳞状细胞癌的结外扩散相关

Sandulache, Vlad C; Michikawa, Chieko; Kataria, Pranav; Gleber-Netto, Frederico O; Bell, Diana; Trivedi, Sanchit; Rao, Xiayu; Wang, Jing; Zhao, Mei; Jasser, Samar; Myers, Jeffrey N; Pickering, Curtis R