Supplementation of L-aspartate corrects MASLD and MASH in mice by inhibiting platelet-hepatocyte interaction-mediated mitochondrial fragmentation via the ATP-P2X7-NEK7-DRP1 axis.
补充 L-天冬氨酸可通过抑制血小板-肝细胞相互作用介导的线粒体断裂（通过 ATP-P2X7-NEK7-DRP1 轴）来纠正小鼠的 MASLD 和 MASH。
期刊:Experimental and Molecular Medicine
影响因子:12.9
doi:10.1038/s12276-026-01648-9
Cao Wen-Jie, Su Rui, Fu Hui-Ling, Wu Jun-Jie, Huang Lin-Sheng, Liu Fei-Fei, Liu Jin, Jiang Zhong-Ping, Xu Cong-Jun, Rao Yong, Huang Ling
