日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein-Coupled Receptors

靶向G蛋白偶联受体的治疗性抗体发现与开发进展

Hutchings, Catherine J; Ünsal, Serbülent; Rappas, Mathieu; Barnes, Matthew; Waldhoer, Maria; Holland, Ben; Culka, Martin

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

混合挤出:高粘度样品注入在时间分辨蛋白质晶体学中的应用

Vakili, Mohammad; Han, Huijong; Schmidt, Christina; Wrona, Agnieszka; Kloos, Marco; de Diego, Iñaki; Dörner, Katerina; Geng, Tian; Kim, Chan; Koua, Faisal H M; Melo, Diogo V M; Rappas, Mathieu; Round, Adam; Round, Ekaterina; Sikorski, Marcin; Valerio, Joana; Zhou, Tiankun; Lorenzen, Kristina; Schulz, Joachim

Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis

使用 X 射线晶体学和计算分析比较 Orexin 1 和 Orexin 2 配体结合模式

Mathieu Rappas, Ammar A E Ali, Kirstie A Bennett, Jason D Brown, Sarah J Bucknell, Miles Congreve, Robert M Cooke, Gabriella Cseke, Chris de Graaf, Andrew S Doré, James C Errey, Ali Jazayeri, Fiona H Marshall, Jonathan S Mason, Richard Mould, Jayesh C Patel, Benjamin G Tehan, Malcolm Weir, John A Ch

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

DNA损伤检查点蛋白TOPBP1/Rad4的BRCT结构域对磷酸肽配体表现出不同的特异性。

Day, Matthew; Rappas, Mathieu; Ptasinska, Katie; Boos, Dominik; Oliver, Antony W; Pearl, Laurence H

Crystal structure of the GLP-1 receptor bound to a peptide agonist

GLP-1 受体与肽激动剂结合的晶体结构

Ali Jazayeri, Mathieu Rappas, Alastair J H Brown, James Kean, James C Errey, Nathan J Robertson, Cédric Fiez-Vandal, Stephen P Andrews, Miles Congreve, Andrea Bortolato, Jonathan S Mason, Asma H Baig, Iryna Teobald, Andrew S Doré, Malcolm Weir, Robert M Cooke, Fiona H Marshall

Intracellular allosteric antagonism of the CCR9 receptor

CCR9 受体的细胞内变构拮抗作用

Christine Oswald, Mathieu Rappas, James Kean, Andrew S Doré, James C Errey, Kirstie Bennett, Francesca Deflorian, John A Christopher, Ali Jazayeri, Jonathan S Mason, Miles Congreve, Robert M Cooke, Fiona H Marshall

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1)

Rad4(TopBP1) 介导的 DNA 损伤检查点装置的磷酸化依赖性组装和协调

Qu, Meng; Rappas, Mathieu; Wardlaw, Christopher P; Garcia, Valerie; Ren, Jing-Yi; Day, Matthew; Carr, Antony M; Oliver, Antony W; Du, Li-Lin; Pearl, Laurence H

Organization of an activator-bound RNA polymerase holoenzyme

激活剂结合RNA聚合酶全酶的组织

Daniel Bose, Tillmann Pape, Patricia C Burrows, Mathieu Rappas, Siva R Wigneshweraraj, Martin Buck, Xiaodong Zhang

Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity

人类RECQ1的不同四级结构与其双重酶活性相关。

Muzzolini, Laura; Beuron, Fabienne; Patwardhan, Ardan; Popuri, Venkateswarlu; Cui, Sheng; Niccolini, Benedetta; Rappas, Mathieu; Freemont, Paul S; Vindigni, Alessandro