日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ATR promotes mTORC1 activity via de novo cholesterol synthesis

ATR通过从头合成胆固醇促进mTORC1活性。

Naveen Kumar Tangudu ,Alexandra N Grumet ,Richard Fang ,Raquel Buj ,Aidan R Cole ,Apoorva Uboveja ,Amandine Amalric ,Baixue Yang ,Zhentai Huang ,Cassandra Happe ,Mai Sun ,Stacy L Gelhaus ,Matthew L MacDonald ,Nadine Hempel ,Nathaniel W Snyder ,Katarzyna M Kedziora ,Alexander J Valvezan ,Katherine M Aird

De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

从头嘌呤代谢是 p16 表达低的癌症的代谢弱点

Naveen Kumar Tangudu #, Raquel Buj #, Hui Wang, Jiefei Wang, Aidan R Cole, Apoorva Uboveja, Richard Fang, Amandine Amalric, Baixue Yang, Adam Chatoff, Claudia V Crispim, Peter Sajjakulnukit, Maureen A Lyons, Kristine Cooper, Nadine Hempel, Costas A Lyssiotis, Uma R Chandran, Nathaniel W Snyder, Kath

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

αKG 介导的肉碱合成通过组蛋白乙酰化促进同源重组

Apoorva Uboveja, Zhentai Huang, Raquel Buj, Amandine Amalric, Hui Wang, Naveen Kumar Tangudu, Aidan R Cole, Emily Megill, Daniel Kantner, Adam Chatoff, Hafsah Ahmad, Mariola M Marcinkiewicz, Julie A Disharoon, Sarah Graff, Erika S Dahl, Nadine Hempel, Wayne Stallaert, Simone Sidoli, Benjamin G Bitle

ATM inhibition drives metabolic adaptation via induction of macropinocytosis

ATM抑制通过诱导巨胞饮作用来驱动代谢适应

Zhentai Huang #, Chi-Wei Chen #, Raquel Buj, Naveen Kumar Tangudu, Richard S Fang, Kelly E Leon, Erika S Dahl, Erika L Varner, Eliana von Krusenstiern, Aidan R Cole, Nathaniel W Snyder, Katherine M Aird

ATR promotes mTORC1 activation via de novo cholesterol synthesis in p16-low cancer cells

ATR 通过 p16 低癌细胞中的从头胆固醇合成促进 mTORC1 活化

Naveen Kumar Tangudu, Zhentai Huang, Richard Fang, Raquel Buj, Apoorva Uboveja, Aidan R Cole, Cassandra Happe, Mai Sun, Stacy L Gelhaus, Matthew L MacDonald, Nadine Hempel, Nathaniel W Snyder, Katherine M Aird

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression

从头嘌呤代谢是 p16 表达低的癌症的代谢弱点

Naveen Kumar Tangudu, Raquel Buj, Hui Wang, Jiefei Wang, Aidan R Cole, Apoorva Uboveja, Richard Fang, Amandine Amalric, Peter Sajjakulnukit, Maureen A Lyons, Kristine Cooper, Nadine Hempel, Nathaniel W Snyder, Costas A Lyssiotis, Uma R Chandran, Katherine M Aird

DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A

DOT1L 通过 IL1A 的表观遗传调控来调节衰老相关的分泌表型

Kelly E Leon, Raquel Buj, Elizabeth Lesko, Erika S Dahl, Chi-Wei Chen, Naveen Kumar Tangudu, Yuka Imamura-Kawasawa, Andrew V Kossenkov, Ryan P Hobbs, Katherine M Aird

Suppression of p16 alleviates the senescence-associated secretory phenotype

抑制 p16 可减轻衰老相关的分泌表型

Raquel Buj, Kelly E Leon, Marlyn A Anguelov, Katherine M Aird

Molecular profiling for acromegaly treatment: a validation study

肢端肥大症治疗的分子分析:一项验证研究

Manel Puig-Domingo, Joan Gil, Miguel Sampedro-Nuñez, Mireia Jordà, Susan M Webb, Guillermo Serra, Laura Pons, Isabel Salinas, Alberto Blanco, Montserrat Marques-Pamies, Elena Valassi, Antonio Picó, Araceli García-Martínez, Cristina Carrato, Raquel Buj, Carlos Del Pozo, Gabriel Obiols, Carles Villabo

ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells

ATM 抑制与非诺贝特在高级别浆液性卵巢癌细胞中产生协同作用

Chi-Wei Chen, Raquel Buj, Erika S Dahl, Kelly E Leon, Katherine M Aird