日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A "Ligand First" Approach toward Selective, Covalent JNK2/3 Inhibitors.

以“配体优先”为导向的选择性共价 JNK2/3 抑制剂策略

Wydra Valentin R, Plank Nicole, Zwirner Stefan, Selig Roland, Rasch Alexander, Masberg Benedikt, Lämmerhofer Michael, Zender Lars, Koch Pierre, Albrecht Wolfgang, Laufer Stefan

Discovery of the First Highly Selective 1,4-dihydropyrido[3,4-b]pyrazin-3(2H)-one MKK4 Inhibitor.

发现首个高选择性 1,4-二氢吡啶并[3,4-b]吡嗪-3(2H)-酮 MKK4 抑制剂

Katzengruber Leon, Sander Pascal, Zwirner Stefan, Rasch Alexander, Eberlein Eric, Selig Roland, Albrecht Wolfgang, Zender Lars, Laufer Stefan A

A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2

剧情出现转折:从JAK3中酪氨酸的共价靶向转变为MK2中赖氨酸的共价靶向。

Hillebrand, Laura; Wang, Guiqun; Rasch, Alexander; Masberg, Benedikt; Chaikuad, Apirat; Kronenberger, Thales; Günther, Ellen; Forster, Michael; Poso, Antti; Lämmerhofer, Michael; Laufer, Stefan A; Knapp, Stefan; Gehringer, Matthias

Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors

向EGFR突变体选择性倾斜:扩大二价“V型”激酶抑制剂的范围

Wittlinger, Florian; Chitnis, Surbhi P; Pham, Calvin D; Damghani, Tahereh; Patel, Kishan B; Möllers, Mareike; Schaeffner, Ilse K; Abidakun, Omobolanle A; Deng, Matthew Q; Ogboo, Blessing C; Rasch, Alexander; Beyett, Tyler S; Buckley, Brian; Feru, Frederic; Shaurova, Tatiana; Knappe, Cornelius; Eck, Michael J; Hershberger, Pamela A; Scott, David A; Brandt, Asher L; Laufer, Stefan A; Heppner, David E

Correction to "Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity"

对“靶向组织蛋白酶的SARS-CoV-2抑制剂:设计、合成和生物活性”的更正

Flury, Philipp; Breidenbach, Julian; Krüger, Nadine; Voget, Rabea; Schäkel, Laura; Si, Yaoyao; Krasniqi, Vesa; Calistri, Sara; Olfert, Matthias; Sylvester, Katharina; Rocha, Cheila; Ditzinger, Raphael; Rasch, Alexander; Pöhlmann, Stefan; Kronenberger, Thales; Poso, Antti; Rox, Katharina; Laufer, Stefan A; Müller, Christa E; Gütschow, Michael; Pillaiyar, Thanigaimalai