Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer
通过 PDE4D 抑制重新激活 cAMP 通路代表了一种新的药物轴,可克服 ER 阳性乳腺癌对他莫昔芬的耐药性
期刊:Clinical Cancer Research
影响因子:10
doi:10.1158/1078-0432.CCR-17-2776
Rasmi R Mishra, Nevin Belder, Suhail A Ansari, Merve Kayhan, Hilal Bal, Umar Raza, Pelin G Ersan, Ünal M Tokat, Erol Eyüpoğlu, Özge Saatci, Pouria Jandaghi, Stefan Wiemann, Ayşegül Üner, Caglar Cekic, Yasser Riazalhosseini, Özgür Şahin
信号转导
肿瘤
乳腺癌
GPCR/Calcium/cAMP