T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells
针对 EGFR 的 T 细胞结合 BiTE 抗体可有效清除 KRAS 和 BRAF 突变的结直肠癌细胞。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1000976107
Lutterbuese, Ralf; Raum, Tobias; Kischel, Roman; Hoffmann, Patrick; Mangold, Susanne; Rattel, Benno; Friedrich, Matthias; Thomas, Oliver; Lorenczewski, Grit; Rau, Doris; Schaller, Evelyne; Herrmann, Ines; Wolf, Andreas; Urbig, Thomas; Baeuerle, Patrick A; Kufer, Peter
肿瘤
肠癌
T细胞
肿瘤免疫
EGF
BRAF
EGFR
细胞生物学
RAS