In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis
对S-MRI-1867（一种治疗Hermansky-Pudlak综合征肺纤维化的候选药物）进行体外和体内药代动力学表征、手性转化以及PBPK模型向人体药代动力学模拟的缩放。
期刊:Biomedicine & Pharmacotherapy
影响因子:7.5
doi:10.1016/j.biopha.2023.115178
Padilha, Elias C; Yang, Mengbi; Shah, Pranav; Wang, Amy Q; Duan, Jianmin; Park, Joshua K; Zawatsky, Charles N; Malicdan, May Christine V; Kunos, George; Iyer, Malliga R; Gaucher, Geneviève; Ravenelle, François; Cinar, Resat; Xu, Xin
