Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.

全身性 TAK-242 可预防雄性小鼠（而非雌性小鼠）鞘内注射 LPS 诱发的痛觉过敏，并可预防雄性和雌性小鼠足底注射福尔马林后出现的迟发性异常性疼痛：TLR4 在持续性疼痛状态发展中的作用