日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis

mTOR失调诱导IL-6和旁分泌AT2细胞衰老,从而阻碍淋巴管肌瘤病中的肺修复。

Babaei-Jadidi, Roya; Clements, Debbie; Wu, Yixin; Chen, Ken; Miller, Suzanne; Platé, Manuela; Lim, Kyungtae; Rue, Ryan; Krymskaya, Vera P; Chambers, Rachel; Rawlins, Emma L; Xu, Yan; Johnson, Simon R

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

一种新型的人类胎肺来源的肺泡类器官模型揭示了与间质性肺疾病相关的表面活性蛋白C成熟的机制。

Lim, Kyungtae; Rutherford, Eimear N; Delpiano, Livia; He, Peng; Lin, Weimin; Sun, Dawei; Van den Boomen, Dick J H; Edgar, James R; Bang, Jae Hak; Predeus, Alexander; Teichmann, Sarah A; Marioni, John C; Matesic, Lydia E; Lee, Joo-Hyeon; Lehner, Paul J; Marciniak, Stefan J; Rawlins, Emma L; Dickens, Jennifer A

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing.

肺泡类器官的内源基因编辑显示,致病变异体 SFTPC-I73T 的表达会破坏内体功能、上皮极性和伤口愈合

Rutherford Eimear N, Sun Dawei, Lim Kyungtae, Edgar James R, Matesic Lydia E, Marciniak Stefan J, Rawlins Emma L, Dickens Jennifer A

Autophagy dysregulation via the USP20-ULK1 axis in the HERC2-related neurodevelopmental disorder

HERC2 相关神经发育障碍中通过 USP20-ULK1 轴导致的自噬失调

Joan Sala-Gaston, Eva M Pérez-Villegas, José A Armengol, Lettie E Rawlins, Emma L Baple, Andrew H Crosby, Francesc Ventura, Jose Luis Rosa

In vitro platform to model the function of ionocytes in the human airway epithelium

用于模拟人呼吸道上皮细胞中离子细胞功能的体外平台

Vilà-González, Marta; Pinte, Laetitia; Fradique, Ricardo; Causa, Erika; Kool, Heleen; Rodrat, Mayuree; Morell, Carola Maria; Al-Thani, Maha; Porter, Linsey; Guo, Wenrui; Maeshima, Ruhina; Hart, Stephen L; McCaughan, Frank; Granata, Alessandra; Sheppard, David N; Floto, R Andres; Rawlins, Emma L; Cicuta, Pietro; Vallier, Ludovic

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

多种族全基因组关联分析提高了影响肺功能和慢性阻塞性肺疾病风险的基因和通路的分辨率。

Shrine, Nick; Izquierdo, Abril G; Chen, Jing; Packer, Richard; Hall, Robert J; Guyatt, Anna L; Batini, Chiara; Thompson, Rebecca J; Pavuluri, Chandan; Malik, Vidhi; Hobbs, Brian D; Moll, Matthew; Kim, Wonji; Tal-Singer, Ruth; Bakke, Per; Fawcett, Katherine A; John, Catherine; Coley, Kayesha; Piga, Noemi Nicole; Pozarickij, Alfred; Lin, Kuang; Millwood, Iona Y; Chen, Zhengming; Li, Liming; Wijnant, Sara R A; Lahousse, Lies; Brusselle, Guy; Uitterlinden, Andre G; Manichaikul, Ani; Oelsner, Elizabeth C; Rich, Stephen S; Barr, R Graham; Kerr, Shona M; Vitart, Veronique; Brown, Michael R; Wielscher, Matthias; Imboden, Medea; Jeong, Ayoung; Bartz, Traci M; Gharib, Sina A; Flexeder, Claudia; Karrasch, Stefan; Gieger, Christian; Peters, Annette; Stubbe, Beate; Hu, Xiaowei; Ortega, Victor E; Meyers, Deborah A; Bleecker, Eugene R; Gabriel, Stacey B; Gupta, Namrata; Smith, Albert Vernon; Luan, Jian'an; Zhao, Jing-Hua; Hansen, Ailin F; Langhammer, Arnulf; Willer, Cristen; Bhatta, Laxmi; Porteous, David; Smith, Blair H; Campbell, Archie; Sofer, Tamar; Lee, Jiwon; Daviglus, Martha L; Yu, Bing; Lim, Elise; Xu, Hanfei; O'Connor, George T; Thareja, Gaurav; Albagha, Omar M E; Suhre, Karsten; Granell, Raquel; Faquih, Tariq O; Hiemstra, Pieter S; Slats, Annelies M; Mullin, Benjamin H; Hui, Jennie; James, Alan; Beilby, John; Patasova, Karina; Hysi, Pirro; Koskela, Jukka T; Wyss, Annah B; Jin, Jianping; Sikdar, Sinjini; Lee, Mikyeong; May-Wilson, Sebastian; Pirastu, Nicola; Kentistou, Katherine A; Joshi, Peter K; Timmers, Paul R H J; Williams, Alexander T; Free, Robert C; Wang, Xueyang; Morrison, John L; Gilliland, Frank D; Chen, Zhanghua; Wang, Carol A; Foong, Rachel E; Harris, Sarah E; Taylor, Adele; Redmond, Paul; Cook, James P; Mahajan, Anubha; Lind, Lars; Palviainen, Teemu; Lehtimäki, Terho; Raitakari, Olli T; Kaprio, Jaakko; Rantanen, Taina; Pietiläinen, Kirsi H; Cox, Simon R; Pennell, Craig E; Hall, Graham L; Gauderman, W James; Brightling, Chris; Wilson, James F; Vasankari, Tuula; Laitinen, Tarja; Salomaa, Veikko; Mook-Kanamori, Dennis O; Timpson, Nicholas J; Zeggini, Eleftheria; Dupuis, Josée; Hayward, Caroline; Brumpton, Ben; Langenberg, Claudia; Weiss, Stefan; Homuth, Georg; Schmidt, Carsten Oliver; Probst-Hensch, Nicole; Jarvelin, Marjo-Riitta; Morrison, Alanna C; Polasek, Ozren; Rudan, Igor; Lee, Joo-Hyeon; Sayers, Ian; Rawlins, Emma L; Dudbridge, Frank; Silverman, Edwin K; Strachan, David P; Walters, Robin G; Morris, Andrew P; London, Stephanie J; Cho, Michael H; Wain, Louise V; Hall, Ian P; Tobin, Martin D

Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

作者更正:多祖先全基因组关联分析提高了影响肺功能和慢性阻塞性肺疾病风险的基因和通路的分辨率。

Shrine, Nick; Izquierdo, Abril G; Chen, Jing; Packer, Richard; Hall, Robert J; Guyatt, Anna L; Batini, Chiara; Thompson, Rebecca J; Pavuluri, Chandan; Malik, Vidhi; Hobbs, Brian D; Moll, Matthew; Kim, Wonji; Tal-Singer, Ruth; Bakke, Per; Fawcett, Katherine A; John, Catherine; Coley, Kayesha; Piga, Noemi Nicole; Pozarickij, Alfred; Lin, Kuang; Millwood, Iona Y; Chen, Zhengming; Li, Liming; Wijnant, Sara R A; Lahousse, Lies; Brusselle, Guy; Uitterlinden, Andre G; Manichaikul, Ani; Oelsner, Elizabeth C; Rich, Stephen S; Barr, R Graham; Kerr, Shona M; Vitart, Veronique; Brown, Michael R; Wielscher, Matthias; Imboden, Medea; Jeong, Ayoung; Bartz, Traci M; Gharib, Sina A; Flexeder, Claudia; Karrasch, Stefan; Gieger, Christian; Peters, Annette; Stubbe, Beate; Hu, Xiaowei; Ortega, Victor E; Meyers, Deborah A; Bleecker, Eugene R; Gabriel, Stacey B; Gupta, Namrata; Smith, Albert Vernon; Luan, Jian'an; Zhao, Jing-Hua; Hansen, Ailin F; Langhammer, Arnulf; Willer, Cristen; Bhatta, Laxmi; Porteous, David; Smith, Blair H; Campbell, Archie; Sofer, Tamar; Lee, Jiwon; Daviglus, Martha L; Yu, Bing; Lim, Elise; Xu, Hanfei; O'Connor, George T; Thareja, Gaurav; Albagha, Omar M E; Suhre, Karsten; Granell, Raquel; Faquih, Tariq O; Hiemstra, Pieter S; Slats, Annelies M; Mullin, Benjamin H; Hui, Jennie; James, Alan; Beilby, John; Patasova, Karina; Hysi, Pirro; Koskela, Jukka T; Wyss, Annah B; Jin, Jianping; Sikdar, Sinjini; Lee, Mikyeong; May-Wilson, Sebastian; Pirastu, Nicola; Kentistou, Katherine A; Joshi, Peter K; Timmers, Paul R H J; Williams, Alexander T; Free, Robert C; Wang, Xueyang; Morrison, John L; Gilliland, Frank D; Chen, Zhanghua; Wang, Carol A; Foong, Rachel E; Harris, Sarah E; Taylor, Adele; Redmond, Paul; Cook, James P; Mahajan, Anubha; Lind, Lars; Palviainen, Teemu; Lehtimäki, Terho; Raitakari, Olli T; Kaprio, Jaakko; Rantanen, Taina; Pietiläinen, Kirsi H; Cox, Simon R; Pennell, Craig E; Hall, Graham L; Gauderman, W James; Brightling, Chris; Wilson, James F; Vasankari, Tuula; Laitinen, Tarja; Salomaa, Veikko; Mook-Kanamori, Dennis O; Timpson, Nicholas J; Zeggini, Eleftheria; Dupuis, Josée; Hayward, Caroline; Brumpton, Ben; Langenberg, Claudia; Weiss, Stefan; Homuth, Georg; Schmidt, Carsten Oliver; Probst-Hensch, Nicole; Jarvelin, Marjo-Riitta; Morrison, Alanna C; Polasek, Ozren; Rudan, Igor; Lee, Joo-Hyeon; Sayers, Ian; Rawlins, Emma L; Dudbridge, Frank; Silverman, Edwin K; Strachan, David P; Walters, Robin G; Morris, Andrew P; London, Stephanie J; Cho, Michael H; Wain, Louise V; Hall, Ian P; Tobin, Martin D

HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

HERC2 缺乏可激活 C-RAF/MKK3/p38 信号通路,改变细胞对氧化应激的反应

Joan Sala-Gaston, Leonardo Pedrazza, Juanma Ramirez, Arturo Martinez-Martinez, Lettie E Rawlins, Emma L Baple, Andrew H Crosby, Ugo Mayor, Francesc Ventura, Jose Luis Rosa

Open questions in human lung organoid research

人类肺类器官研究中尚未解决的问题

Hughes, Tessa; Dijkstra, Krijn K; Rawlins, Emma L; Hynds, Robert E

The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease

人类肺细胞图谱:健康和疾病状态下人类肺的高分辨率参考图谱

Schiller, Herbert B; Montoro, Daniel T; Simon, Lukas M; Rawlins, Emma L; Meyer, Kerstin B; Strunz, Maximilian; Vieira Braga, Felipe A; Timens, Wim; Koppelman, Gerard H; Budinger, G R Scott; Burgess, Janette K; Waghray, Avinash; van den Berge, Maarten; Theis, Fabian J; Regev, Aviv; Kaminski, Naftali; Rajagopal, Jayaraj; Teichmann, Sarah A; Misharin, Alexander V; Nawijn, Martijn C