日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PAM-flexible genome editing with an engineered chimeric Cas9

利用工程嵌合 Cas9 进行 PAM 灵活的基因组编辑

Lin Zhao, Sabrina R T Koseki, Rachel A Silverstein, Nadia Amrani, Christina Peng, Christian Kramme, Natasha Savic, Martin Pacesa, Tomás C Rodríguez, Teodora Stan, Emma Tysinger, Lauren Hong, Vivian Yudistyra, Manvitha R Ponnapati, Joseph M Jacobson, George M Church, Noah Jakimo, Ray Truant, Martin J

PAM-Flexible Genome Editing with an Engineered Chimeric Cas9

利用工程嵌合 Cas9 进行 PAM 灵活基因组编辑

Sabrina Koseki, Lauren Hong, Vivian Yudistyra, Teodora Stan, Emma Tysinger, Rachel Silverstein, Christian Kramme, Nadia Amrani, Natasha Savic, Martin Pacesa, Tomás Rodriguez, Manvitha Ponnapati, Joseph Jacobson, George Church, Ray Truant, Martin Jinek, Benjamin Kleinstiver, Erik Sontheimer, Pranam C

Mod3D: A low-cost, flexible modular system of live-cell microscopy chambers and holders

Mod3D:一种低成本、灵活的活细胞显微镜室和支架模块化系统

Siobhan Goss, Carlos Barba Bazan, Kaitlyn Neuman, Christina Peng, Nola Begeja, Celeste Elisabeth Suart, Ray Truant

Functional characterization of variants of unknown significance in a spinocerebellar ataxia patient using an unsupervised machine learning pipeline

使用无监督机器学习流程对脊髓小脑共济失调患者中意义不明的变异进行功能表征

Siddharth Nath, Nicholas S Caron, Linda May, Oxana B Gluscencova, Jill Kolesar, Lauren Brady, Brett A Kaufman, Gabrielle L Boulianne, Amadeo R Rodriguez, Mark A Tarnopolsky, Ray Truant

Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology

揭示亨廷顿氏病的新原理:血液如何传播和改善疾病病理

Marie Rieux #, Melanie Alpaugh #, Giacomo Sciacca, Martine Saint-Pierre, Maria Masnata, Hélèna L Denis, Sébastien A Lévesque, Frank Herrmann, Chantal Bazenet, Alexandre P Garneau, Paul Isenring, Ray Truant, Abid Oueslati, Peter V Gould, Anne Ast, Erich E Wanker, Steve Lacroix, Francesca Cicchetti

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

亨廷顿蛋白结构由 HAP40 调控,并与外显子 1 发生多聚谷氨酰胺扩增特异性相互作用

Rachel J Harding, Justin C Deme, Johannes F Hevler, Sem Tamara, Alexander Lemak, Jeffrey P Cantle, Magdalena M Szewczyk, Nola Begeja, Siobhan Goss, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B Carroll, Albert J R Heck, Susan M Lea,

High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry

高迁移率族蛋白 B1 连接亨廷顿蛋白对活性氧的感知和其进入核

Susie Son, Laura E Bowie, Tamara Maiuri, Claudia L K Hung, Carly R Desmond, Jianrun Xia, Ray Truant

A patient-derived cellular model for Huntington's disease reveals phenotypes at clinically relevant CAG lengths

亨廷顿氏病患者衍生的细胞模型揭示了临床相关的 CAG 长度的表型

Claudia Lin-Kar Hung, Tamara Maiuri, Laura Erin Bowie, Ryan Gotesman, Susie Son, Mina Falcone, James Victor Giordano, Tammy Gillis, Virginia Mattis, Trevor Lau, Vickie Kwan, Vanessa Wheeler, Jonathan Schertzer, Karun Singh, Ray Truant

N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation

N6-糠基腺嘌呤通过信号传导亨廷顿蛋白磷酸化,在亨廷顿病模型中发挥保护作用

Laura E Bowie, Tamara Maiuri, Melanie Alpaugh, Michelle Gabriel, Nicolas Arbez, Danny Galleguillos, Claudia L K Hung, Shreya Patel, Jianrun Xia, Nicholas T Hertz, Christopher A Ross, David W Litchfield, Simonetta Sipione, Ray Truant

DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants

DIXDC1 磷酸化和树突形态的控制受到罕见遗传变异的损害

Vickie Kwan, Durga Praveen Meka, Sean H White, Claudia L Hung, Nicholas T Holzapfel, Susan Walker, Nadeem Murtaza, Brianna K Unda, Birgit Schwanke, Ryan K C Yuen, Kendra Habing, Chloe Milsom, Kristin J Hope, Ray Truant, Stephen W Scherer, Froylan Calderon de Anda, Karun K Singh