日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

致病真菌中 Hsp90 物种选择性靶向的结构基础

Luke Whitesell, Nicole Robbins, David S Huang, Catherine A McLellan, Tanvi Shekhar-Guturja, Emmanuelle V LeBlanc, Catherine S Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L Xie, Damian J Krysan, Susan Lindquist, John A Porco Jr, Utpal Tatu, Lau

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation

疟原虫中 cGMP 依赖性蛋白激酶的结构揭示了一种独特的激活结构中继机制

Majida El Bakkouri, Imène Kouidmi, Amy K Wernimont, Mehrnaz Amani, Ashley Hutchinson, Peter Loppnau, Jeong Joo Kim, Christian Flueck, John R Walker, Alma Seitova, Guillermo Senisterra, Yoshito Kakihara, Choel Kim, Michael J Blackman, Charles Calmettes, David A Baker, Raymond Hui

Discovery of a PCAF Bromodomain Chemical Probe

PCAF 溴结构域化学探针的发现

Moses Moustakim, Peter G K Clark, Laura Trulli, Angel L Fuentes de Arriba, Matthias T Ehebauer, Apirat Chaikuad, Emma J Murphy, Jacqui Mendez-Johnson, Danette Daniels, Chun-Feng D Hou, Yu-Hui Lin, John R Walker, Raymond Hui, Hongbing Yang, Lucy Dorrell, Catherine M Rogers, Octovia P Monteiro, Oleg F

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

布氏锥虫中不存在磷酸葡糖变位酶,而是由磷酸甘露糖变位酶和磷酸-N-乙酰葡萄糖胺变位酶冗余替代

Giulia Bandini, Karina Mariño, M Lucia Sampaio Güther, Amy K Wernimont, Sabine Kuettel, Wei Qiu, Shamshad Afzal, Anna Kelner, Raymond Hui, Michael A J Ferguson

Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding

疟原虫过氧化物酶的晶体结构:对寡聚化和产物结合的新见解

Wei Qiu, Aiping Dong, Juan C Pizarro, Alexei Botchkarsev, Jinrong Min, Amy K Wernimont, Tanya Hills, Raymond Hui, Jennifer D Artz

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei

布氏锥虫葡萄糖胺 6-磷酸 N-乙酰转移酶的表征、定位、必要性和高分辨率晶体结构

Karina Mariño, M Lucia Sampaio Güther, Amy K Wernimont, Wei Qiu, Raymond Hui, Michael A J Ferguson

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

N-肉豆蔻酰转移酶抑制剂作为治疗昏睡病的新线索

Julie A Frearson, Stephen Brand, Stuart P McElroy, Laura A T Cleghorn, Ondrej Smid, Laste Stojanovski, Helen P Price, M Lucia S Guther, Leah S Torrie, David A Robinson, Irene Hallyburton, Chidochangu P Mpamhanga, James A Brannigan, Anthony J Wilkinson, Michael Hodgkinson, Raymond Hui, Wei Qiu, Olawa

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence

弓形虫分泌激酶对免疫相关 GTP 酶的磷酸化促进巨噬细胞存活和毒力

Sarah J Fentress, Michael S Behnke, Ildiko R Dunay, Mona Mashayekhi, Leah M Rommereim, Barbara A Fox, David J Bzik, Gregory A Taylor, Benjamin E Turk, Cheryl F Lichti, R Reid Townsend, Wei Qiu, Raymond Hui, Wandy L Beatty, L David Sibley

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase

布氏锥虫UDP-葡萄糖焦磷酸化酶的鉴定、亚细胞定位、生化特性和高分辨率晶体结构

Karina Mariño, Maria Lucia Sampaio Güther, Amy K Wernimont, Mernhaz Amani, Raymond Hui, Michael A J Ferguson

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii

弓形虫棒状分泌激酶的新结构和调控特征

Wei Qiu, Amy Wernimont, Keliang Tang, Sonya Taylor, Vladimir Lunin, Matthieu Schapira, Sarah Fentress, Raymond Hui, L David Sibley