日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy

利用 CD200-CD200R 免疫检查点轴增强多发性骨髓瘤中的 CAR-T 细胞疗法

Yan Tang ,Wei Liu ,Siddhant Kadu ,Omar Johnson ,Zainul S Hasanali ,Andre Kelly ,Alexander Shestov ,Raymone Pajarillo ,Eli Greenblatt ,Matthew Holmes ,Li-Ping Wang ,Natalie Shih ,Roddy S O'Connor ,Marco Ruella ,Alfred L Garfall ,David Allman ,Dan T Vogl ,Adam Cohen ,Carl H June ,Neil C Sheppard

Streamlined measurement of chimeric antigen receptor T-cell concentration, size, viability and two-color phenotyping during manufacturing

生产过程中对嵌合抗原受体T细胞的浓度、大小、活力和双色表型进行简化测量

Raymone Pajarillo ,Luca Paruzzo ,Alberto Carturan ,Ositadimma Ugwuanyi ,Griffin White ,Puneeth Guruprasad ,Hatcher J Ballard ,Ruchi P Patel ,Yunlin Zhang ,Yong Gu Lee ,Seok Jae Albert Hong ,Gregory M Dittami ,Marco Ruella

Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study

一种新型抗CD19嵌合抗原受体T细胞产品(靶向CD19膜近端结构域,具有快速结合和解离速率)治疗非霍奇金淋巴瘤的安全性和有效性:一项首次人体研究

Yunlin Zhang # ,Ruchi P Patel # ,Ki Hyun Kim # ,Hyungwoo Cho # ,Jae-Cheol Jo ,Seong Hyun Jeong ,Sung Yong Oh ,Yoon Seok Choi ,Sung Hyun Kim ,Ji Hyun Lee ,Mathew Angelos ,Puneeth Guruprasad ,Ivan Cohen ,Ositadimma Ugwuanyi ,Yong Gu Lee ,Raymone Pajarillo ,Jong Hyun Cho ,Alberto Carturan ,Luca Paruzzo ,Guido Ghilardi ,Michael Wang ,Soohwan Kim ,Sung-Min Kim ,Hyun-Jong Lee ,Ji-Ho Park ,Leiguang Cui ,Tae Bum Lee ,In-Sik Hwang ,Young-Ha Lee ,Yong-Jun Lee ,Patrizia Porazzi ,Dongfang Liu ,Yoon Lee ,Jong-Hoon Kim ,Jong-Seo Lee ,Dok Hyun Yoon ,Junho Chung ,Marco Ruella

Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy

调节肠道菌群参与抗原交叉呈递,从而增强 CAR-T 细胞免疫疗法的抗肿瘤作用

Mireia Uribe-Herranz, Silvia Beghi, Marco Ruella, Kalpana Parvathaneni, Silvano Salaris, Nektarios Kostopoulos, Subin S George, Stefano Pierini, Elisavet Krimitza, Francesca Costabile, Guido Ghilardi, Kimberly V Amelsberg, Yong Gu Lee, Raymone Pajarillo, Caroline Markmann, Bevin McGettigan-Croce, Di

Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer

调节 T 细胞和肿瘤细胞中的 BCL-2 以增强嵌合抗原受体 T 细胞抗癌免疫疗法

Yong Gu Lee, Puneeth Guruprasad, Guido Ghilardi, Raymone Pajarillo, Christopher Tor Sauter, Ruchi Patel, Hatcher J Ballard, Seok Jae Hong, Inkook Chun, Nicholas Yang, Kimberly V Amelsberg, Katherine D Cummins, Jakub Svoboda, Saar Gill, Elise A Chong, Khrystyna North, Sarah E Church, Joseph A Fraiett

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

抗原非依赖性激活可增强 4-1BB 共刺激 CD22 CAR T 细胞的功效

Nathan Singh #, Noelle V Frey #, Boris Engels #, David M Barrett, Olga Shestova, Pranali Ravikumar, Katherine D Cummins, Yong Gu Lee, Raymone Pajarillo, Inkook Chun, Amy Shyu, Steven L Highfill, Andrew Price, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xueqing Maggie Lu, David A Christ

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

白血病中死亡受体信号传导受损通过诱导CAR T细胞功能障碍导致抗原非依赖性耐药

Nathan Singh #,Yong Gu Lee #,Olga Shestova,Pranali Ravikumar,Katharina E Hayer,Seok Jae Hong,Xueqing Maggie Lu,Raymone Pajarillo,Sangya Agarwal,Shunichiro Kuramitsu,Elena J Orlando,Karen Thudium Mueller,Charly R Good,Shelley L Berger,Ophir Shalem,Matthew D Weitzman,Noelle V Frey,Shannon L Maude,Stephan A Grupp,Carl H June,Saar Gill #,Marco Ruella #