日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery

利用细胞色素P450人源化小鼠模型改进血吸虫病药物研发

Davey, Sarah D; Forde-Thomas, Josephine E; Hulme, Benjamin J; Lees, Kristin; Costain, Alice H; Evans, Mary; Rinaldi, Gabriel; Frame, Laura; Stojanovski, Laste; Simeons, Frederick R C; Tavendale, Amy; MacLeod, A Kenneth; Pichon, Remi; Lee, Yi-Hsuan; Polak, Oktawia; Chalmers, Iain W; Dankwa, Bismark; Odhiambo, Brenda Kisia; Guimaraes, Victor Hugo; Hegarty, Matthew; Swain, Martin T; Aubrey, Wayne; Caldwell, Nicola; MacDonald, Andrew S; Gilbert, Ian H; Baragaña, Beatriz; Read, Kevin D; Hoffmann, Karl F

Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas' disease drug discovery

在恰加斯病药物研发过程中,利用非靶向代谢组学对细胞色素b抑制剂进行筛选

MacLeod, A Kenneth; Tulloch, Lindsay B; Tinti, Michele; Edwards, Darren; Wyllie, Susan; Read, Kevin D

Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis

鉴定和评价二元哌啶类化合物作为新型抗结核分枝杆菌细胞壁抑制剂

Naylor, Claire; Prosser, Gareth A; Bayliss, Tracy; Berle, Lila; Wallach, Joshua B; Kim, Heather; Olvera, Rodrigo Aguilera; Thompson, Stephen; Ioerger, Thomas R; Simpson, Laura; Casanueva, Ruth; Guijarro-Lopez, Laura; Read, Kevin D; Wyatt, Paul G; Schnappinger, Dirk; Barry, Clifton E; Green, Simon R; Boshoff, Helena I; Cleghorn, Laura A T

Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis

赖氨酰tRNA合成酶抑制剂的设计与开发,用于治疗结核病

Davis, Susan H; Mathieson, Michael; Buchanan, Kirsteen I; Dawson, Alice; Smith, Alasdair; Cocco, Mattia; Tamaki, Fabio K; Post, John M; Baragaña, Beatriz; Jansen, Chimed; Kiczun, Michael; Zuccotto, Fabio; Wood, Gavin; Scullion, Paul; Ray, Peter C; Epemolu, Ola; Lopez-Román, Eva Maria; López, Laura Guijarro; Engelhart, Curtis A; Kim, Jia; Pino, Paula A; Schnappinger, Dirk; Read, Kevin D; Encinas, Lourdes; Bates, Robert H; Wyatt, Paul G; Green, Simon R; Cleghorn, Laura A T

Compounds Reducing Human Sperm Motility as Potential Nonhormonal Contraceptives Identified Using a High-Throughput Phenotypic Screening Platform

利用高通量表型筛选平台鉴定出可降低人类精子活力的化合物,这些化合物有望成为非激素避孕药。

Richardson, Anthony; Gruber, Franz S; Day, David P; Edwards, Darren; Georgiou, Irene; Johnston, Zoe C; Joji, Halimatu; Martins da Silva, Sarah; Myles, Rachel; Norcross, Neil R; Read, Kevin D; Swedlow, Jason R; Wilson, Caroline; Barratt, Christopher L R; Gilbert, Ian H

Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs

应用人源化小鼠模型模拟细胞色素P450介导的药物代谢,预测肽类药物与小分子药物之间的药物相互作用

Kapelyukh, Yury; Gabel-Jensen, Charlotte; MacLeod, Alastaire Kenneth; Daniel Coquelin, Kevin-Sebastien; Stojanovski, Laste; Frame, Laura; Tavendale, Amy; Henderson, Colin J; Read, Kevin D; Wolf, Charles Roland; Säll, Carolina

High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer

利用高通量筛选靶向17β-HSD10的强效类药分子,用于治疗阿尔茨海默病和癌症

Aitken, Laura; Baillie, Gemma; Pannifer, Andrew; Morrison, Angus; Major, Louise L; Alphey, Magnus S; Sethi, Ritika; Timmerman, Martin; Robinson, John; Riley, Jennifer; Shishikura, Yoko; Koekemoer, Lizbe; Von Delft, Frank; Rutjes, Helma; Read, Kevin D; Jones, Philip S; McElroy, Stuart P; Smith, Terry K; Gunn-Moore, Frank J

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis

鉴定出一系列含有五氟苯基部分的化合物,该化合物靶向 Pks13 以抑制结核分枝杆菌的生长

Green, Simon R; Harrison, Justin R; Thompson, Stephen; Murugesan, Dinakaran; Libardo, M Daben J; Engelhart, Curtis A; Meshanni, Jaclynn; Fletcher, Daniel; Scullion, Paul; Edwards, Darren; Epemolu, Ola; Mutter, Nicole; Shishikura, Yoko; Riley, Jennifer; Ioerger, Thomas R; Roca Guillén, Jose Juan; López, Laura Guijarro; Read, Kevin D; Barry, Clifton E 3rd; Schnappinger, Dirk; Wyatt, Paul G; Boshoff, Helena I M; Cleghorn, Laura A T

Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery

利用伯氏疟原虫小鼠模型进行药物代谢人源化研究以开发抗疟药物

MacLeod, A Kenneth; Merino, Cristina; Viera-Morilla, Sara; Frame, Laura; Tavendale, Amy; Duncan, Christina; Ferguson, Liam; Pinto, Erika G; Simeons, Frederick R C; Gomez-Jimenez, Vanessa; García, Ana Belén; Riley, Jennifer; Shishikura, Yoko; Martínez-Martínez, María Santos; Wolf, C Roland; Read, Kevin D

Structure-activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

1,5-二氢-2H-苯并[b][1,4]二氮杂卓-2,4(3H)-二酮作为克氏锥虫抑制剂的构效关系

Thomas, Michael G; Dunne, Joanne; Dodd, Peter G; D'Oria, Emiliana; Frame, Laura; Garcia-Perez, Adolfo; McGonagle, Kate; Manzano, Pilar; MacLean, Lorna; Paterson, Christy; Riley, Jennifer; Thomas, John; Torrie, Leah S; Wrobel, Karolina; Read, Kevin D; Marco, Maria; De Rycker, Manu