日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4-激酶(PI4Kβ)的强效抑制剂,是抗疟药物化学优化的理想候选药物。

Woodland, John G; Coertzen, Dina; Wicht, Kathryn J; Hidalgo, Virginia Franco; Pasaje, Charisse Flerida A; Godoy, Luiz C; Qahash, Tarrick; Mmonwa, Mmakwena M; Dziwornu, Godwin A; Wambua, Lynn; Harries, Sarah; Korkor, Constance M; Njoroge, Mathew; Krugmann, Liezl; Taylor, Dale; Leshabane, Meta; Langeveld, Henrico; Rabie, Tayla; Reader, Janette; van der Watt, Mariëtte; Venter, Nelius; Erlank, Erica; Aswat, Ayesha S; Koekemoer, Lizette L; Yeo, Tomas; Jeon, Jin H; Fidock, David A; Gamo, Francisco Javier; Wittlin, Sergio; Niles, Jacquin C; Llinas, Manuel; Coulson, Lauren B; Birkholtz, Lyn-Marié; Chibale, Kelly

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Sapanisertib(一种抗癌药物和双重疟原虫磷脂酰肌醇 4-激酶 β 和 cGMP 依赖性蛋白激酶抑制剂,用于治疗疟疾)的药物化学进展

Gachuhi, Samuel; Kamunya, Stephanie; Fienberg, Stephen; Wambua, Lynn; Salomane, Nicolaas; Mayoka, Godfrey; Taylor, Dale; Coertzen, Dina; van der Watt, Mariette; Reader, Janette; Birkholtz, Lyn-Marié; Wittlin, Sergio; Krugmann, Liezl; Coulson, Lauren B; Chibale, Kelly

Ferrocenyl Quinoline-Benzimidazole Hybrids: A Multistage Strategy to Combat Drug-Resistant Malaria

二茂铁喹啉-苯并咪唑杂合物:对抗耐药疟疾的多阶段策略

Golding, Taryn M; Garnie, Larnelle F; Rabie, Tayla; Reader, Janette; Birkholtz, Lyn-Marié; Wicht, Kathryn J; Smith, Gregory S

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites

阐明阿奇霉素类似物对疟原虫的快速杀灭机制

Mao, Emma Y; Nguyen, William; Jana, Gouranga P; Maity, Bikash C; Pazicky, Samuel; Giannangelo, Carlo; Reader, Janette; Famodimu, Mufuliat T; Birkholtz, Lyn-Marie; Delves, Michael J; Creek, Darren J; Bozdech, Zbynek; Laleu, Benoît; Burrows, Jeremy N; Sleebs, Brad E; Gancheva, Maria R; Wilson, Danny W

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation

人源Chk1抑制剂CHIR-124通过双重抑制PfArk1和血红素形成,对恶性疟原虫表现出多阶段活性。

Wicht, Kathryn J; Woodland, John G; Garnie, Larnelle F; Langeveld, Henrico; Taylor, Dale; Godoy, Luiz C; Pasaje, Charisse Flerida A; de Souza, Mariana Laureano; Siqueira-Neto, Jair L; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Gamo, Francisco-Javier; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte; Bridgford, Jessica L; Girling, Gareth; Coyle, Rachael; Scheurer, Christian; Wittlin, Sergio; Lee, Marcus C S; Voss, Till S; Winzeler, Elizabeth A; Fidock, David A; Niles, Jacquin C; Birkholtz, Lyn-Marié; Coulson, Lauren B; Chibale, Kelly

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

消除疟疾传播需要通过脂质体吸收抗疟药物来靶向未成熟和成熟的配子体。

Naude, Mariska; van Heerden, Ashleigh; Reader, Janette; van der Watt, Mariëtte; Niemand, Jandeli; Joubert, Dorè; Siciliano, Giulia; Alano, Pietro; Njoroge, Mathew; Chibale, Kelly; Herreros, Esperanza; Leroy, Didier; Birkholtz, Lyn-Marié

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

疟原虫环核苷酸磷酸二酯酶抑制剂可阻断无性血液期发育和蚊子传播

Gomez-Gonzalez Paula-Josefina, Gupta Antima, Drought Laura G, Patel Avnish, Okombo John, van der Watt Mariëtte, Walker-Gray Ryan, Schindler Kyra A, Burkhard Anna Y, Yeo Tomas, Narwal Sunil K, Bloxham Talia S, Flueck Christian, Walker Eloise M, Rey Joshua A, Fairhurst Kate J, Reader Janette, Park Heekuk, Pollard Harry G, Stewart Lindsay B, Brandner-Garrod Luke, Kristan Mojca, Sterk Geert-Jan, van Nuland Youri M, Manko Emilia, van Schalkwyk Donelly A, Zheng Yang, Leurs Rob, Dechering Koen J, Aguiar Anna Caroline C, Guido Rafael V C, Pereira Dhelio B, Tumwebaze Patrick K, Nosbya Samuel L, Rosenthal Philip J, Cooper Roland A, Palmer Mike, Parkinson Tanya, Burrows Jeremy N, Uhlemann Anne-Catrin, Birkholtz Lyn-Marié, Small-Saunders Jennifer L, Duffy James, Fidock David A, Brown Alan, Gardner Mark, Baker David A

Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination

适应或灭亡:针对疟疾传播阶段的独特生物学特性进行根除疟疾

van der Watt, Mariëtte E; Reader, Janette; Birkholtz, Lyn-Marié

Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum

针对恶性疟原虫配子体杀灭化合物的精简而稳健的阶段特异性分析

Reader, Janette; van der Watt, Mariette E; Birkholtz, Lyn-Marié

Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors

吸附于血红素晶体表面:基于结构的氨基吩恶嗪β-血红素抑制剂的设计与合成

Olivier, Tania; Loots, Leigh; Kok, Michélle; de Villiers, Marianne; Reader, Janette; Birkholtz, Lyn-Marié; Arnott, Gareth E; de Villiers, Katherine A