日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bacterial ubiquitin ligase engineered for small molecule and protein target identification.

经基因工程改造的细菌泛素连接酶,用于小分子和蛋白质靶标鉴定。

Ye James S, Majumdar Abir, Park Brenden C, Black Miles H, Hsieh Ting-Sung, Osinski Adam, Servage Kelly A, Kulkarni Kartik, Naidoo Jacinth, Alto Neal M, Stratton Margaret M, Alfandari Dominique, Ready Joseph M, Pawłowski Krzysztof, Tomchick Diana R, Tagliabracci Vincent S

Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury

抑制15-PGDH可阻止血脑屏障的破坏,并保护小鼠免受阿尔茨海默病和创伤性脑损伤。

Koh, Yeojung; Vázquez-Rosa, Edwin; Gao, Farrah; Li, Hongyun; Chakraborty, Suwarna; Tripathi, Sunil Jamuna; Barker, Sarah; Bud, Zea; Bangalore, Anusha; Kandjoze, Uapingena P; León-Alvarado, Rose A; Sridharan, Preethy S; Cordova, Brittany A; Yu, Youngmin; Hyung, Jiwon; Fang, Hua; Singh, Salendra; Katabathula, Ramachandra; LaFramboise, Thomas; Kasturi, Lakshmi; Lutterbaugh, James; Beard, Lydia; Cordova, Erika; Cintrón-Pérez, Coral J; Franke, Kathryn; Fragoso, Mariana Franco; Miller, Emiko; Indrakumar, Vidya; Noel, Kamryn L; Dhar, Matasha; Ajroud, Kaouther; Zamudio, Carlos; Lopes, Filipa Blasco Tavares Pereira; Bambakidis, Evangeline; Zhu, Xiongwei; Wilson, Brigid; Flanagan, Margaret E; Gefen, Tamar; Fujioka, Hisashi; Fink, Stephen P; Desai, Amar B; Dawson, Dawn; Williams, Noelle S; Kim, Young-Kwang; Ready, Joseph M; Paul, Bindu D; Shin, Min-Kyoo; Markowitz, Sanford D; Pieper, Andrew A

Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine.

通过活性位点半胱氨酸对 SARS-CoV-2 NiRAN 结构域进行共价抑制

Hernandez Genaro, Osinski Adam, Majumdar Abir, Eitson Jennifer L, Antczak Monika, Pawłowski Krzysztof, Niederstrasser Hanspeter, Servage Kelly A, Posner Bruce, Schoggins John W, Ready Joseph M, Tagliabracci Vincent S

Bacterial ubiquitin ligase engineered for small molecule and protein target identification.

经基因工程改造的细菌泛素连接酶,用于小分子和蛋白质靶标鉴定

Ye James S, Majumdar Abir, Park Brenden C, Black Miles H, Hsieh Ting-Sung, Osinski Adam, Servage Kelly A, Kulkarni Kartik, Naidoo Jacinth, Alto Neal M, Stratton Margaret M, Alfandari Dominique, Ready Joseph M, Pawłowski Krzysztof, Tomchick Diana R, Tagliabracci Vincent S

Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.

鉴定出强效且可逆的哌啶甲酰胺类化合物,它们是具有物种选择性的口服活性蛋白酶体抑制剂,可用于治疗疟疾

Lawong Aloysus, Gahalawat Suraksha, Ray Sneha, Ho Nhi, Han Yan, Ward Kurt E, Deng Xiaoyi, Chen Zhe, Kumar Ashwani, Xing Chao, Hosangadi Varun, Fairhurst Kate J, Tashiro Kyuto, Liszczak Glen, Shackleford David M, Katneni Kasiram, Chen Gong, Saunders Jessica, Crighton Elly, Casas Arturo, Robinson Joshua J, Imlay Leah S, Zhang Xiaoyu, Lemoff Andrew, Zhao Zhiyu, Angulo-Barturen Iñigo, Jiménez-Díaz María Belén, Wittlin Sergio, Campbell Simon F, Fidock David A, Laleu Benoît, Charman Susan A, Ready Joseph M, Phillips Margaret A

Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers.

烟酰胺的噻吩基衍生物通过 NAD 补救途径代谢为非天然 NAD 衍生物,这些衍生物抑制 IMPDH,对周围神经癌具有毒性

Theodoropoulos Panayotis C, Guo Holly H, Wang Wentian, Crossley Eric, Rivera Cancel Giomar, Fang Min, Nguyen Thu, Baniasadi Hamid, Williams Noelle S, Ready Joseph M, De Brabander Jef K, Nijhawan Deepak

Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes

利用烯基硼酸酯络合物对活化的含氮杂环进行非对映选择性烷基化

McGettigan, James E Jr; Ready, Joseph M

Asymmetric Catalytic Hydroboration of Enol Carbamates Enables an Enantioselective Matteson Homologation

烯醇氨基甲酸酯的不对称催化氢硼化反应可实现对映选择性马特森同系化反应

Kuznetsov, Dmitry M; Ready, Joseph M

A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support

第二代 15-PGDH 抑制剂可促进骨髓移植后的恢复,且该作用独立于年龄、移植剂量和粒细胞集落刺激因子支持。

Desai, Amar; Zhang, Yongyou; Park, Youngsoo; Dawson, Dawn M; Larusch, Gretchen A; Kasturi, Lakshmi; Wald, David; Ready, Joseph M; Gerson, Stanton L; Markowitz, Sanford D

Palladium Catalyzed Asymmetric Three-Component Coupling of Boronic Esters, Indoles, and Allylic Acetates

钯催化硼酸酯、吲哚和烯丙基乙酸酯的不对称三组分偶联反应

Panda, Santanu; Ready, Joseph M