日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium

利用大规模扰动谱汇编阐明化合物的作用机制和多药理学

Hu, Lucas ZhongMing; Hirschhorn, Tal; Douglass, Eugene; Murray, Diana; Trudeau, Stephen J; Turunen, Mikko; Pampou, Sergey; Grunn, Adina; Realubit, Ron; Antolin, Albert A; Wang, Alexander L E; Li, Hai; Subramaniam, Prem; Mundi, Prabhjot S; Karan, Charles; Alvarez, Mariano; Honig, Barry; Stockwell, Brent R; Califano, Andrea

Systematic elucidation and pharmacologic targeting on non-oncogene dependencies in imatinib-resistant gastrointestinal stromal tumor

系统阐明和药物靶向治疗伊马替尼耐药性胃肠道间质瘤中的非癌基因依赖性

Mundi, Prabhjot S; Grunn, Adina; Kojadinovic, Arsenije; Karan, Charles; Realubit, Ronald; Caescu, Cristina I; Hibshoosh, Hanina; Aburi, Mahalaxmi; Alvarez, Mariano J; Ingham, Matthew; Evans, Denisse; Rothschild, Sara; Schwartz, Gary K; Califano, Andrea

Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators

系统阐明和药理学靶向肿瘤浸润调节性T细胞主调控因子

Aleksandar Obradovic ,Casey Ager ,Mikko Turunen ,Thomas Nirschl ,Mohsen Khosravi-Maharlooei ,Alina Iuga ,Christopher M Jackson ,Srinivasan Yegnasubramanian ,Lorenzo Tomassoni ,Ester Calvo Fernandez ,Patrick McCann ,Meri Rogava ,Angelo M DeMarzo ,Christina M Kochel ,Mohamad Allaf ,Trinity Bivalacqua ,Michael Lim ,Ronald Realubit ,Charles Karan ,Charles G Drake ,Andrea Califano

OncoLoop: A Network-Based Precision Cancer Medicine Framework

OncoLoop:基于网络的精准癌症医学框架

Vasciaveo, Alessandro; Arriaga, Juan Martín; de Almeida, Francisca Nunes; Zou, Min; Douglass, Eugene F; Picech, Florencia; Shibata, Maho; Rodriguez-Calero, Antonio; de Brot, Simone; Mitrofanova, Antonina; Chua, Chee Wai; Karan, Charles; Realubit, Ronald; Pampou, Sergey; Kim, Jaime Y; Afari, Stephanie N; Mukhammadov, Timur; Zanella, Luca; Corey, Eva; Alvarez, Mariano J; Rubin, Mark A; Shen, Michael M; Califano, Andrea; Abate-Shen, Cory

A Transcriptome-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies.

基于转录组的精准肿瘤学平台,用于针对多种难治性恶性肿瘤的患者-治疗方案匹配

Mundi Prabhjot S, Dela Cruz Filemon S, Grunn Adina, Diolaiti Daniel, Mauguen Audrey, Rainey Allison R, Guillan Kristina, Siddiquee Armaan, You Daoqi, Realubit Ronald, Karan Charles, Ortiz Michael V, Douglass Eugene F, Accordino Melissa, Mistretta Suzanne, Brogan Frances, Bruce Jeffrey N, Caescu Cristina I, Carvajal Richard D, Crew Katherine D, Decastro Guarionex, Heaney Mark, Henick Brian S, Hershman Dawn L, Hou June Y, Iwamoto Fabio M, Jurcic Joseph G, Kiran Ravi P, Kluger Michael D, Kreisl Teri, Lamanna Nicole, Lassman Andrew B, Lim Emerson A, Manji Gulam A, McKhann Guy M, McKiernan James M, Neugut Alfred I, Olive Kenneth P, Rosenblat Todd, Schwartz Gary K, Shu Catherine A, Sisti Michael B, Tergas Ana, Vattakalam Reena M, Welch Mary, Wenske Sven, Wright Jason D, Canoll Peter, Hibshoosh Hanina, Kalinsky Kevin, Aburi Mahalaxmi, Sims Peter A, Alvarez Mariano J, Kung Andrew L, Califano Andrea

Discovering Venom-Derived Drug Candidates Using Differential Gene Expression

利用差异基因表达发现毒液衍生的候选药物

Romano, Joseph D; Li, Hai; Napolitano, Tanya; Realubit, Ronald; Karan, Charles; Holford, Mandë; Tatonetti, Nicholas P

A community challenge for a pancancer drug mechanism of action inference from perturbational profile data

社区挑战:从扰动概况数据推断泛癌药物作用机制

Eugene F Douglass Jr, Robert J Allaway, Bence Szalai, Wenyu Wang, Tingzhong Tian, Adrià Fernández-Torras, Ron Realubit, Charles Karan, Shuyu Zheng, Alberto Pessia, Ziaurrehman Tanoli, Mohieddin Jafari, Fangping Wan, Shuya Li, Yuanpeng Xiong, Miquel Duran-Frigola, Martino Bertoni, Pau Badia-I-Mompel,

A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection

基于网络的病毒感染诱导的异常复制促进性转录程序的识别和药理学靶向模型

Laise, Pasquale; Stanifer, Megan L; Bosker, Gideon; Sun, Xiaoyun; Triana, Sergio; Doldan, Patricio; La Manna, Federico; De Menna, Marta; Realubit, Ronald B; Pampou, Sergey; Karan, Charles; Alexandrov, Theodore; Kruithof-de Julio, Marianna; Califano, Andrea; Boulant, Steeve; Alvarez, Mariano J

A Model for Network-Based Identification and Pharmacological Targeting of Aberrant, Replication-Permissive Transcriptional Programs Induced by Viral Infection

基于网络的病毒感染诱导的异常复制促进型转录程序的识别和药理学靶向模型

Laise, Pasquale; Stanifer, Megan L; Bosker, Gideon; Sun, Xiaoyun; Triana, Sergio; Doldan, Patricio; La Manna, Federico; De Menna, Marta; Realubit, Ronald B; Pampou, Sergey; Karan, Charles; Alexandrov, Theodore; Kruithof-de Julio, Marianna; Califano, Andrea; Boulant, Steeve; Alvarez, Mariano J

TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

启动子和内含子上的 TOP2B 酶活性调节人类胶质瘤中的多种致癌基因

Edgar Gonzalez-Buendia #, Junfei Zhao #, Lu Wang, Subhas Mukherjee, Daniel Zhang, Víctor A Arrieta, Eric Feldstein, J Robert Kane, Seong Jae Kang, Catalina Lee-Chang, Aayushi Mahajan, Li Chen, Ronald Realubit, Charles Karan, Lisa Magnuson, Craig Horbinski, Stacy A Marshall, Jann N Sarkaria, Ahmed Mo