日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Longitudinal deep multi-omics profiling in a CLN3(Δex7/8) minipig model identifies biomarker signatures of disease

在CLN3(Δex7/8)小型猪模型中进行纵向深度多组学分析,鉴定出疾病的生物标志物特征。

Rechtzigel, Mitchell J; Lee, Brittany; Neville, Christine; Huang, Ting; Díaz, Ramón; Campos, Alex Rosa; Motamedchaboki, Khatereh; Hornburg, Daniel; Johnson, Tyler B; Swier, Vicki J; Weimer, Jill M; Brudvig, Jon J

Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease

治疗性反义寡核苷酸可减轻CLN3巴顿病猪模型中的视网膜功能障碍

Stratton, Matthew P; Centa, Jessica L; Swier, Vicki J; Pfeifer, Wanda L; Booth, Clarissa D; Albert, Karlee; Hunyara, John L; Rechtzigel, Mitchell J; Duelli, Fox J; Leppert, Hannah G; Rigo, Frank; Smit, Trisha; Jafar-Nejad, Paymaan; Weimer, Jill M; Drack, Arlene V; Hastings, Michelle L

Mutation in Wdr45 leads to early motor dysfunction and widespread aberrant axon terminals in a beta-propeller protein associated neurodegeneration (BPAN) patient-inspired mouse model

Wdr45 基因突变会导致 β-螺旋桨蛋白相关神经退行性疾病 (BPAN) 患者模型中出现早期运动功能障碍和广泛的异常轴突末梢。

Meyerink, Brandon L; Karia, Krishna S; Rechtzigel, Mitchell J; Patthi, Prithvi R; Edwards, Ariana C; Howard, Jessica M; Aaseng, Elizabeth R; Aftab, Shamiq; Weimer, Jill M; Pilaz, Louis-Jan

Predictive biomarkers and initial analysis of maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology

产后先兆子痫的预测性生物标志物和母体免疫改变的初步分析揭示了一种免疫驱动的病理

Camille Couture, Marie-Eve Brien, Jade Rechtzigel, SuYun Ling, Cecilia Ledezma-Soto, Gilberto Duran Bishop, Ines Boufaied, Dorothée Dal Soglio, Evelyne Rey, Serge McGraw, Charles H Graham, Sylvie Girard

NF1+/ex42del miniswine model the cellular disruptions and behavioral presentations of NF1-associated cognitive and motor impairment

NF1+/ex42del 小型猪模拟 NF1 相关认知和运动障碍的细胞破坏和行为表现

Vicki J Swier, Katherine A White, Pedro L Negrão de Assis, Tyler B Johnson, Hannah G Leppert, Mitchell J Rechtzigel, David K Meyerholz, Rebecca D Dodd, Dawn E Quelle, Rajesh Khanna, Christopher S Rogers, Jill M Weimer

Pharmacist-driven outreach initiative to increase prescribing of sodium-glucose cotransporter-2 inhibitors in eligible VHA patients with chronic kidney disease: a study protocol

药剂师主导的推广计划旨在提高符合条件的退伍军人事务部慢性肾病患者使用钠-葡萄糖协同转运蛋白2抑制剂的比例:一项研究方案

Pestka, Deborah L; Murphy, Daniel; Huynh, Pearl; Rechtzigel, Jessica A; Kjos, Shari; Ellich, Lisa Marie; Kaplan, Adam N; Taylor, Brent C; Atwood, Melissa; Polsfuss, Beth A; Lee, Joseph Y; Ishani, Areef

Sortilin inhibition treats multiple neurodegenerative lysosomal storage disorders

Sortilin 抑制剂可治疗多种神经退行性溶酶体贮积症

Hannah G Leppert, Joelle T Anderson, Kaylie J Timm, Cristina Davoli, Melissa A Pratt, Clarissa D Booth, Katherine A White, Mitchell J Rechtzigel, Brandon L Meyerink, Tyler B Johnson, Jon J Brudvig, Jill M Weimer

Glycerophosphoinositol is Elevated in Blood Samples From CLN3 (Δex7-8) pigs, Cln3 (Δex7-8) Mice, and CLN3-Affected Individuals

CLN3 (Δex7-8) 猪、CLN3 (Δex7-8) 小鼠和 CLN3 患者血液样本中的甘油磷酸肌醇水平升高

Brudvig, Jon J; Swier, Vicki J; Johnson, Tyler B; Cain, Jacob C; Pratt, Melissa; Rechtzigel, Mitch; Leppert, Hannah; Dang Do, An N; Porter, Forbes D; Weimer, Jill M