日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

dHyperCas12a enables multiplexed CRISPRi screens

dHyperCas12a 可实现多路复用 CRISPRi 屏幕

Melore, Schuyler M; McRoberts Amador, Christian D; Hamilton, Marisa C; Gersbach, Charles A; Reddy, Timothy E

The IGVF catalog-from genetic variation to function

IGVF目录——从基因变异到功能

Li, Daofeng; Liu, Shane; Assis, Pedro R; Li, Mingjie; Dong, Shengcheng; Whaling, Ian; Jolanki, Otto; Kagda, Meenakshi; Zhang, Wenjin; Macias-Velasco, Juan F; Liu, Tianjie; Cody, Sarah; Antonacci-Fulton, Lucinda; Huang, Yuanhao; Liu, Jie; Montgomery, Michael T; Zeiberg, Daniel; Jain, Shantanu; Pejaver, Vikas; Bergquist, Timothy; Chen, Yile; Radivojac, Predrag; Gersbach, Charles A; Sherpa, Rintsen N; Castro, Christopher P; Boyle, Alan P; Starita, Lea M; Fowler, Douglas M; Ahituv, Nadav; Dey, Kushal K; Majoros, William H; Reddy, Timothy E; Craven, Mark; Sinha, Riya; Sverchkov, Yuriy; Cai, Xiangmeng; Nzima, Mpathi Z; Calderwood, Michael A; Rozowsky, Joel; Gerstein, Mark; Ma, Jian; Yue, Feng; Cherry, J Michael; Love, Michael I; Engreitz, Jesse M; Hitz, Benjamin C; Wang, Ting

Identifying Inheritance Patterns of Allelic Imbalance, using Integrative Modeling and Bayesian Inference

利用整合建模和贝叶斯推断识别等位基因失衡的遗传模式

Hoyt, Stephanie H; Reddy, Timothy E; Gordân, Raluca; Allen, Andrew S; Majoros, William H

Enhancer hubs govern chromatin topology and Th17 cell identity

增强子中心调控染色质拓扑结构和Th17细胞特性

Siklenka, Keith; Zhang, Chuangchuang; Li, Liqing; Parker, Morgan; Mehta, Naren; Barrera, Alejandro; Venukuttan, Revathy; Crawford, Gregory E; Gersbach, Charles A; Ciofani, Maria; Reddy, Timothy E

Modeling gene regulatory perturbations via deep learning from high-throughput reporter assays

利用高通量报告基因检测,通过深度学习模拟基因调控扰动

Venukuttan, Revathy; Doty, Richard; Thomson, Alexander; Chen, Yutian; Li, Boyao; Duan, Yuncheng; Barrera, Alejandro; Dura, Katherine; Ko, Kuei-Yueh; Lapp, Hilmar; Reddy, Timothy E; Allen, Andrew S; Majoros, William H

Structured Pooling Improves Detection of Rare Regulatory Mutations in Population-Scale Reporter Assays

结构化混合方法可提高群体规模报告基因检测中罕见调控突变的检出率

Dura, Katherine; Siklenka, Keith; Strause, Kari; Morrow, Shauna; Zhang, Chuangchuang; Barrera, Alejandro; Allen, Andrew S; Reddy, Timothy E; Majoros, William H

Cell modeling and rescue of a novel noncoding genetic cause of glycogen storage disease IX.

细胞建模和拯救一种新的非编码遗传性糖原贮积症病因 IX。

Iyengar Apoorva K, Zou Xue, Dai Jian, Francis Rhodricia A, Safi Alexias, Patterson Karynne, Koch Rebecca L, Clarke Shannon, Beaman M Makenzie, Mohan Shruthi, Chong Jessica X, Bamshad Michael J, Majoros William H, Rehder R Catherine, Bali Deeksha S, Allen Andrew S, Crawford Gregory E, Kishnani Priya S, Reddy Timothy E

Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone production.

与多囊卵巢综合征相关的基因调控活动揭示了 DENND1A 依赖的睾酮生成

Sankaranarayanan Laavanya, Brewer Kelly J, Morrow Shauna, Johnson Graham D, Barrera Alejandro, Venukuttan Revathy, Sisk Ryan, Dunaif Andrea, Reddy Timothy E

Comprehensive evaluation of diverse massively parallel reporter assays to functionally characterize human enhancers genome-wide

对多种大规模并行报告基因检测方法进行全面评估,以从全基因组范围内表征人类增强子的功能。

Zhang, Junke; Leung, Alden King-Yung; Zhu, Yutong; Yao, Li; Willis, Avery; Pan, Xiuqi; Ozer, Abdullah; Zhou, Zhou; Siklenka, Keith; Barrera, Alejandro; Liang, Jin; Tippens, Nathaniel D; Reddy, Timothy E; Lis, John T; Yu, Haiyuan

Promoter Deletion Leading to Allele Specific Expression in a Genetically Unsolved Case of Primary Ciliary Dyskinesia

启动子缺失导致原发性纤毛运动障碍病例中等位基因特异性表达,该病例的遗传病因尚未明确

Beaman, M Makenzie; Yin, Weining; Smith, Amanda J; Sears, Patrick R; Leigh, Margaret W; Ferkol, Thomas W; Kearney, Brendan; Olivier, Kenneth N; Kimple, Adam J; Clarke, Shannon; Huggins, Erin; Nading, Erica; Jung, Seung-Hye; Iyengar, Apoorva K; Zou, Xue; Dang, Hong; Barrera, Alejandro; Majoros, William H; Rehder, Catherine W; Reddy, Timothy E; Ostrowski, Lawrence E; Allen, Andrew S; Knowles, Michael R; Zariwala, Maimoona A; Crawford, Gregory E