Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers
通过联合使用 αCTLA-4 和 αPD-1 阻断剂来克服具有高肿瘤诱导中性粒细胞水平的 MMR 缺陷肿瘤对 αPD-1 的抵抗力
期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.3
doi:10.1136/jitc-2022-005059
Laetitia Nebot-Bral, Antoine Hollebecque #, Andrey A Yurchenko #, Louise de Forceville, Mathieu Danjou, Jean-Mehdi Jouniaux, Reginaldo C A Rosa, Caroline Pouvelle, Said Aoufouchi, Perrine Vuagnat, Cristina Smolenschi, Emeline Colomba, Alexandra Leary, Aurelien Marabelle, Jean-Yves Scoazec, Lydie Cas
肿瘤
粒细胞
Cell Depletion
Functional/Block/Neutralize
WB
Mouse
CTLA4