日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

全基因组分析鉴定出25个不孕症基因位点,并揭示了这些位点与等位基因频率范围内生殖性状的关联。

Venkatesh, Samvida S; Wittemans, Laura B L; Palmer, Duncan S; Baya, Nikolas A; Ferreira, Teresa; Hill, Barney; Lassen, Frederik Heymann; Parker, Melody J; Reibe, Saskia; Elhakeem, Ahmed; Banasik, Karina; Bruun, Mie T; Erikstrup, Christian; Aagard Jensen, Bitten; Juul, Anders; Mikkelsen, Christina; Nielsen, Henriette S; Ostrowski, Sisse R; Pedersen, Ole B; Rohde, Palle Duun; Sørensen, Erik; Ullum, Henrik; Westergaard, David; Haraldsson, Asgeir; Holm, Hilma; Jonsdottir, Ingileif; Olafsson, Isleifur; Steingrimsdottir, Thora; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Figueredo, Jessica; Karjalainen, Minna K; Pasanen, Anu; Jacobs, Benjamin M; Kalantzis, Georgios; Hubers, Nikki; Lippincott, Margaret; Fraser, Abigail; Lawlor, Deborah A; Timpson, Nicholas J; Nyegaard, Mette; Stefansson, Kari; Magi, Reedik; Laivuori, Hannele; van Heel, David A; Boomsma, Dorret I; Balasubramanian, Ravikumar; Seminara, Stephanie B; Chan, Yee-Ming; Laisk, Triin; Lindgren, Cecilia M

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution

结合人类遗传和功能筛选的证据,识别影响肥胖和脂肪分布的通路

Baya, Nikolas A; Sur Erdem, Ilknur; Venkatesh, Samvida S; Reibe, Saskia; Charles, Philip D; Navarro-Guerrero, Elena; Hill, Barney; Lassen, Frederik H; Claussnitzer, Melina; Palmer, Duncan S; Lindgren, Cecilia M

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution

结合人类基因和功能筛查的证据来确定改变肥胖和脂肪分布的途径

Nikolas A Baya, Ilknur Sur Erdem, Samvida S Venkatesh, Saskia Reibe, Philip D Charles, Elena Navarro-Guerrero, Barney Hill, Frederik Heymann Lassen, Melina Claussnitzer, Duncan S Palmer, Cecilia M Lindgren

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum

全基因组分析在等位基因频率范围内鉴定出21个不孕症基因位点和400多个生殖激素基因位点。

Venkatesh, Samvida S; Wittemans, Laura B L; Palmer, Duncan S; Baya, Nikolas A; Ferreira, Teresa; Hill, Barney; Lassen, Frederik Heymann; Parker, Melody J; Reibe, Saskia; Elhakeem, Ahmed; Banasik, Karina; Bruun, Mie T; Erikstrup, Christian; Jensen, Bitten A; Juul, Anders; Mikkelsen, Christina; Nielsen, Henriette S; Ostrowski, Sisse R; Pedersen, Ole B; Rohde, Palle D; Sorensen, Erik; Ullum, Henrik; Westergaard, David; Haraldsson, Asgeir; Holm, Hilma; Jonsdottir, Ingileif; Olafsson, Isleifur; Steingrimsdottir, Thora; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Figueredo, Jessica; Karjalainen, Minna K; Pasanen, Anu; Jacobs, Benjamin M; Hubers, Nikki; Lippincott, Margaret; Fraser, Abigail; Lawlor, Deborah A; Timpson, Nicholas J; Nyegaard, Mette; Stefansson, Kari; Magi, Reedik; Laivuori, Hannele; van Heel, David A; Boomsma, Dorret I; Balasubramanian, Ravikumar; Seminara, Stephanie B; Chan, Yee-Ming; Laisk, Triin; Lindgren, Cecilia M

Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC

治疗性阻断内质网应激和炎症可预防 NASH 和进展为 HCC

Ebru Boslem, Saskia Reibe, Rodrigo Carlessi, Benoit Smeuninx, Surafel Tegegne, Casey L Egan, Emma McLennan, Lauren V Terry, Max Nobis, Andre Mu, Cameron Nowell, Neil Horadagoda, Darren C Henstridge, Natalie A Mellett, Paul Timpson, Matthew Jones, Elena Denisenko, Alistair R R Forrest, Janina E E Tir

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

β细胞功能受胰岛相关巨噬细胞的代谢和表观遗传编程调控,涉及Axl、Mertk和TGFβ受体信号传导。

Le May Thai ,Liam O'Reilly ,Saskia Reibe-Pal ,Nancy Sue ,Holly Holliday ,Lewin Small ,Carsten Schmitz-Peiffer ,Rama Dhenni ,Vicky Wang-Wei Tsai ,Nicholas Norris ,Belinda Yau ,Xuan Zhang ,Kailun Lee ,Chenxu Yan ,Yan-Chuan Shi ,Melkam A Kebede ,Robert Brink ,Gregory J Cooney ,Katharine M Irvine ,Samuel N Breit ,Tri G Phan ,Alexander Swarbrick ,Trevor J Biden

Fructose stimulated de novo lipogenesis is promoted by inflammation

炎症会促进果糖刺激的从头脂肪生成。

Jelena Todoric ,Giuseppe Di Caro ,Saskia Reibe ,Darren C Henstridge ,Courtney R Green ,Alison Vrbanac ,Fatih Ceteci ,Claire Conche ,Reginald McNulty ,Shabnam Shalapour ,Koji Taniguchi ,Peter J Meikle ,Jeramie D Watrous ,Rafael Moranchel ,Mahan Najhawan ,Mohit Jain ,Xiao Liu ,Tatiana Kisseleva ,Maria T Diaz-Meco ,Jorge Moscat ,Rob Knight ,Florian R Greten ,Lester F Lau ,Christian M Metallo ,Mark A Febbraio ,Michael Karin

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

脂肪组织中(而非肝脏中)的蛋白激酶 C Epsilon 缺失可改善葡萄糖耐受性

Amanda E Brandon, Bing M Liao, Barbara Diakanastasis, Benjamin L Parker, Katy Raddatz, Sophie A McManus, Liam O'Reilly, Erica Kimber, A Gabrielle van der Kraan, Dale Hancock, Darren C Henstridge, Peter J Meikle, Gregory J Cooney, David E James, Saskia Reibe, Mark A Febbraio, Trevor J Biden, Carsten

Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer

结直肠癌基因缺失突变小鼠模型揭示炎症和癌症的新途径

Nicola Currey, Zeenat Jahan, C Elizabeth Caldon, Phuong N Tran, Fahad Benthani, Penelope De Lacavalerie, Daniel L Roden, Brian S Gloss, Claudia Campos, Elaine G Bean, Amanda Bullman, Saskia Reibe-Pal, Marcel E Dinger, Mark A Febbraio, Stephen J Clarke, Jane E Dahlstrom, Maija R J Kohonen-Corish

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

有证据表明 TLR4 不是饱和脂肪酸受体,而是通过重编程巨噬细胞代谢介导脂质诱导的炎症

Graeme I Lancaster, Katherine G Langley, Nils Anton Berglund, Helene L Kammoun, Saskia Reibe, Emma Estevez, Jacquelyn Weir, Natalie A Mellett, Gerard Pernes, James R W Conway, Man K S Lee, Paul Timpson, Andrew J Murphy, Seth L Masters, Steve Gerondakis, Nenad Bartonicek, Dominik C Kaczorowski, Marce