日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protocol to evaluate mouse brain spatial cell type-resolved transcriptomic discoveries using 10× Visium spatial transcriptomics and FLEX scRNA-seq.

使用 10× Visium 空间转录组学和 FLEX scRNA-seq 评估小鼠脑空间细胞类型解析转录组学发现的方案。

Burns Mara S, Miramontes Ricardo, Reidling John C, Lim Ryan G, Thompson Leslie M

Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification.

亨廷顿病中的异常剪接伴随着 TDP-43 活性的破坏和 m6A RNA 修饰的改变

Nguyen Thai B, Miramontes Ricardo, Chillon-Marinas Carlos, Maimon Roy, Vazquez-Sanchez Sonia, Lau Alice L, McClure Nicolette R, Wu Zhuoxing, Wang Keona Q, England Whitney E, Singha Monika, Stocksdale Jennifer T, Heath Marie, Jang Ki-Hong, Jung Sunhee, Ling Karen, Jafar-Nejad Paymann, McKnight Jharrayne I, Ho Leanne N, Dalahmah Osama Al, Faull Richard L M, Steffan Joan S, Reidling Jack C, Jang Cholsoon, Lee Gina, Cleveland Don W, Lagier-Tourenne Clotilde, Spitale Robert C, Thompson Leslie M

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics.

R6/2 HD 小鼠脑中独特的分子模式:来自时空转录组学的启示

Burns Mara S, Miramontes Ricardo, Wu Jie, Gulia Ravinder, Saddala Madhu S, Lau Alice L, Quach Tiffany, Reidling John C, Swarup Vivek, La Spada Albert R, Lim Ryan G, Thompson Leslie M

Dysregulation of protein SUMOylation networks in Huntington's disease R6/2 mouse striatum.

亨廷顿病 R6/2 小鼠纹状体中蛋白质 SUMO 化网络失调

Kachemov Marketta, Vaibhav Vineet, Smith Charlene, Sundararaman Niveda, Heath Marie, Pendlebury Devon F, Matlock Andrea, Lau Alice, Morozko Eva, Lim Ryan G, Reidling Jack, Steffan Joan S, Van Eyk Jennifer E, Thompson Leslie M

PIAS1/PIAS4-Mediated SUMOylation of TDP-43 Is Induced by Oxidative Stress

氧化应激诱导PIAS1/PIAS4介导的TDP-43 SUMO化。

Pendlebury, Devon F; Truong, Khloe; Heath, Marie; Reidling, Jack C; Sarkar, Partha; Thompson, Leslie M

Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins

亨廷顿蛋白含有泛素结合域,可调节线粒体和 RNA 结合蛋白的溶酶体靶向性

Gianna M Fote, Vinay V Eapen, Ryan G Lim, Clinton Yu, Lisa Salazar, Nicolette R McClure, Jharrayne McKnight, Thai B Nguyen, Marie C Heath, Alice L Lau, Mark A Villamil, Ricardo Miramontes, Ian H Kratter, Steven Finkbeiner, Jack C Reidling, Joao A Paulo, Peter Kaiser, Lan Huang, David E Housman, Lesl

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum

移植的人类神经干细胞可挽救zQ175亨廷顿病小鼠的表型并支配纹状体。

Sandra M Holley,Jack C Reidling,Carlos Cepeda,Jie Wu,Ryan G Lim,Alice Lau,Cindy Moore,Ricardo Miramontes,Brian Fury,Iliana Orellana,Michael Neel,Dane Coleal-Bergum,Edwin S Monuki,Gerhard Bauer,Charles K Meshul,Michael S Levine,Leslie M Thompson

Aberrant splicing in Huntington's disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification

亨廷顿病中异常剪接的发生是由于TDP-43活性受损以及m6A RNA修饰改变所致。

Nguyen, Thai B; Miramontes, Ricardo; Chillon-Marinas, Carlos; Maimon, Roy; Vazquez-Sanchez, Sonia; Lau, Alice L; McClure, Nicolette R; England, Whitney E; Singha, Monika; Stocksdale, Jennifer T; Jang, Ki-Hong; Jung, Sunhee; McKnight, Jharrayne I; Ho, Leanne N; Faull, Richard L M; Steffan, Joan S; Reidling, Jack C; Jang, Cholsoon; Lee, Gina; Cleveland, Don W; Lagier-Tourenne, Clotilde; Spitale, Robert C; Thompson, Leslie M

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

单核 RNA 测序显示亨廷顿病少突胶质细胞成熟缺陷可通过补充硫胺素-生物素来挽救

Ryan G Lim #, Osama Al-Dalahmah #, Jie Wu #, Maxwell P Gold, Jack C Reidling, Guomei Tang, Miriam Adam, David K Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M Reyes-Ortiz, Alice Lau, Richard A Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

亨廷顿病 iPSC 和小鼠星形胶质细胞的单核转录组分析表明成熟和功能缺陷

Andrea M Reyes-Ortiz, Edsel M Abud, Mara S Burns, Jie Wu, Sarah J Hernandez, Nicolette McClure, Keona Q Wang, Corey J Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W Poon, Ryan G Lim, Leslie M Thomps