日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rare genetic variants confer a high risk of ADHD and implicate neuronal biology

罕见基因变异会增加患注意力缺陷多动障碍(ADHD)的风险,并与神经元生物学有关。

Demontis, Ditte; Duan, Jinjie; Hsu, Yu-Han H; Pintacuda, Greta; Grove, Jakob; Nielsen, Trine Tollerup; Thirstrup, Janne; Martorana, Makayla; Botts, Travis; Satterstrom, F Kyle; Bybjerg-Grauholm, Jonas; Tsai, Jason H Y; Glerup, Simon; Hoogman, Martine; Buitelaar, Jan; Klein, Marieke; Ziegler, Georg C; Jacob, Christian; Grimm, Oliver; Bayas, Maximilian; Kobayashi, Nene F; Kittel-Schneider, Sarah; Lesch, Klaus-Peter; Franke, Barbara; Reif, Andreas; Agerbo, Esben; Werge, Thomas; Nordentoft, Merete; Mors, Ole; Mortensen, Preben Bo; Lage, Kasper; Daly, Mark J; Neale, Benjamin M; Børglum, Anders D

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

GH001 vs Placebo in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial

GH001 与安慰剂治疗难治性抑郁症患者的随机临床试验

Cubala, Wieslaw J; Bajbouj, Malek; Bauer, Michael; Baune, Bernhard T; Cardoner, Narcís; Devlin, Fabian; Doolin, Kelly; Dueñas Herrero, Rosa Maria; Elices, Matilde; Feeney, Avril; Galuszko-Wegielnik, Maria; Jakuszkowiak-Wojten, Katarzyna; Janu, Luboš; Kelly, John R; Ledden, Kathryn; Maclsaac, Rachael; Madero, Santiago; McInerney, Shane J; Montejo, Angel L; Nawka, Alexander; Pálenícek, Tomáš; Pérez Solà, Víctor; Ramaekers, Johannes G; Reif, Andreas; Ritter, Philipp; Ryan, Fiona; Svendsen, Claus Bo; Sweeney, Claire; Terwey, Theis H; Trivedi, Madhukar H; Valcheva, Velichka; Vieta, Eduard; Thase, Michael E

A low frequency damaging SORCS2 variant identified in a family with ADHD compromises receptor stability and quenches activity.

在一个患有 ADHD 的家庭中发现了一种低频有害的 SORCS2 变异,这种变异会损害受体稳定性并抑制其活性。

Kaas Mathias, Dinesen Sarah Broholt, Ahlgreen Ole, Madsen Peder, Mølgaard Simon, Dalby Anders, Gustafsen Camilla, Olsen Ditte, Duan Jinjie, Vilstrup Joachim, Lende Jonas, Nordestgaard Sanne, Zayats Tetyana, Knappskog Per Morten, Johansson Stefan, Neckelmann Gesche, Franke Barbara, Thirup Søren, Børglum Anders, Reif Andreas, Vægter Christian, Demontis Ditte, Haavik Jan, Glerup Simon, Skeldal Sune

Household environmental characteristics influence the house dust metagenome

家庭环境特征会影响室内灰尘宏基因组

Gamez, Isabella; Fouladi, Farnaz; Gonzalez, Antonio; Ward, James; Wang, Ziyue; Beane Freeman, Laura E; Motsinger-Reif, Alison; Peddada, Shyamal D; Knight, Rob; Lee, Mikyeong; London, Stephanie J

Acute stress induces changes in epigenome-wide DNA methylation

急性应激诱导表观基因组范围内的DNA甲基化发生改变

Zillich, Lea; Czernin, Nathaly S; Salvador, Oscar Crespo; Hummel, Elisabeth M; Pauli, Paul; Reif, Andreas; Deckert, Jürgen; Domschke, Katharina; Schiele, Miriam A

Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety

基于网络的分析:伴有和不伴有焦虑症的重度抑郁症患者白质连接的差异

Gruber, Marius; Schulte, Jan; Mauritz, Marco; Ahrens, Kira F; Rehm, Paula; von Werthern, Nina M; Staub, Henry; Fischer, Stefanie; Timm, Franka; Libedinsky, Ilan; Grumbach, Pascal; Bonnekoh, Linda M; Goltermann, Janik; Winter, Nils Ralf; Thiel, Katharina; Winter, Alexandra; Borgers, Tiana; Klug, Melissa; Meinert, Hannah; Hubbert, Julia; Krieger, Judith; Jurischka, Christoph; Thomas-Odenthal, Florian; Usemann, Paula; Teutenberg, Lea; Pawlitzki, Marc; Förster, Katharina; Sindermann, Lisa; Böhnlein, Joscha; Meinert, Susanne; Grotegerd, Dominik; Stein, Frederike; Straube, Benjamin; Alexander, Nina; Jamalabadi, Hamidreza; Jansen, Andreas; Nenadić, Igor; Opel, Nils; Hahn, Tim; Bauer, Jochen; van den Heuvel, Martijn P; Reif, Andreas; Kircher, Tilo; Leehr, Elisabeth J; Dannlowski, Udo; Repple, Jonathan

Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort: Results From the DISCOvERIE Project

欧洲多国队列研究中合并其他疾病和精神疾病的肠易激综合征患者疾病负担加重:DISCOvERIE 项目的结果

Midenfjord, Irina; Khadija, Mahrukh; Sundelin, Elias; Trindade, Inês A; Törnblom, Hans; Santos, Javier; Lobo, Beatriz; Mulder, Danique; Vasquez, Alejandro Arias; Ruesing, Georgy; Reif, Andreas; Aichholzer, Mareike; Van Den Houte, Maaike; Van Oudenhove, Lukas; Matteucci, Maria Chiara; Barbara, Giovanni; Bosman, Michelle; Jonkers, Daisy; Ramos-Quiroga, Josep Antoni; Jekkel, Eva; Bitter, István; Pop, Andrei-Vasile; Dumitrascu, Dan Lucian; Alonso-Cotoner, Carmen; Rodríguez-Urrutia, Amanda; Simrén, Magnus

Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style

成人注意力缺陷多动障碍合并重度抑郁症表现出明显的多基因模式和消极的认知风格。

Kranz, Thorsten M; McNeill, Rhiannon V; Jacob, Christian P; Ahrens, Kira F; Neumann, Rebecca J; Plichta, Michael M; Kollmann, Bianca; Streit, Fabian; Tüscher, Oliver; Lieb, Klaus; Weber, Heike; Romanos, Marcel; Lesch, Klaus-Peter; Reif, Andreas; Kittel-Schneider, Sarah; Ziegler, Georg C

Mitochondrial dysfunction in peripheral mononuclear blood cells (PBMC) of individuals with mild cognitive impairment

轻度认知障碍患者外周血单核细胞(PBMC)线粒体功能障碍

Dieter, Fabian; Jacobs, Karlotta; Quentin, Alice; Prvulovic, David; Reif, Andreas; Pantel, Johannes; Pilatus, Ulrich; Hattingen, Elke; Matura, Silke; Eckert, Gunter Peter