Abstinence from cocaine self-administration promotes microglial pruning of astrocytes, which drives cocaine-seeking behavior.
停止可卡因自我给药会促进小胶质细胞修剪星形胶质细胞,从而导致寻求可卡因的行为。
期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2025.116137
Testen Anze, VanRyzin Jonathan W, Bellinger Tania J, Kim Ronald, Wang Han, Gastinger Matthew J, Witt Emily A, Franklin Janay P, Vecchiarelli Haley A, Picard Katherine, Scofield Michael D, Tremblay Marie-Ãve, Reissner Kathryn J