日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules

TAB1-p38α复合物加重心肌损伤,可被小分子靶向

Gian F De Nicola, Rekha Bassi, Charlie Nichols, Mariana Fernandez-Caggiano, Pelin Arabacilar Golforoush, Dibesh Thapa, Rhys Anderson, Eva Denise Martin, Sharwari Verma, Jens Kleinjung, Adam Laing, Jonathan P Hutchinson, Philip Eaton, James Clark, Michael S Marber

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3

p38α丝裂原活化蛋白激酶与丝裂原活化蛋白激酶激酶 3 的氧化还原依赖性二聚化

Rekha Bassi, Joseph R Burgoyne, Gian F DeNicola, Olena Rudyk, Vittorio DeSantis, Rebecca L Charles, Philip Eaton, Michael S Marber

A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580

化学遗传学方法揭示,p38alpha MAPK 通过二磷酸化激活会加重心肌梗死,而 SB203580 的直接结合可阻止这种激活

Sarawut Kumphune, Rekha Bassi, Sebastien Jacquet, Pierre Sicard, James E Clark, Sharwari Verma, Metin Avkiran, Stephen J O'Keefe, Michael S Marber