日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML

BET 抑制剂 Mivebresib (ABBV-075) 在 AML 中的活性联合临床建模

Daniel H Albert, Neal C Goodwin, Angela M Davies, Jenny Rowe, Gerold Feuer, Michael Boyiadzis, Kathleen A Dorritie, Maria Mancini, Regina Gandour-Edwards, Brian A Jonas, Gautam Borthakur, Ibrahim Aldoss, David A Rizzieri, Olatoyosi Odenike, Thomas Prebet, Sanjana Singh, Relja Popovic, Y U Shen, Keit

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis

5-阿扎胞苷诱导 NOXA 引发 AML 细胞发生 Venetoclax 介导的细胞凋亡

Sha Jin #, Dan Cojocari #, Julie J Purkal, Relja Popovic, Nari N Talaty, Yu Xiao, Larry R Solomon, Erwin R Boghaert, Joel D Leverson, Darren C Phillips

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1

GLI2 依赖性 c-MYC 上调介导胰腺癌细胞对 BET 溴结构域抑制剂 JQ1 产生耐药性

Krishan Kumar, Sania S Raza, Lawrence M Knab, Christina R Chow, Benjamin Kwok, David J Bentrem, Relja Popovic, Kazumi Ebine, Jonathan D Licht, Hidayatullah G Munshi

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

组蛋白甲基转移酶 MMSET/NSD2 通过 H3K36 和 H3K27 甲基化的整体和局部变化改变 EZH2 结合并重新编程骨髓瘤表观基因组

Relja Popovic, Eva Martinez-Garcia, Eugenia G Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y Shah, Yupeng Zheng, Christine M Will, Eliza C Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A Calogero, William L Kath, Neil L Kelleher, Ji-Ping Wang, Olivie

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

MLL 对 mir-196b 的调控以及 MLL 融合对其的过度表达有助于永生化

Relja Popovic, Laurie E Riesbeck, Chinavenmeni S Velu, Aditya Chaubey, Jiwang Zhang, Nicholas J Achille, Frank E Erfurth, Katherine Eaton, Jun Lu, H Leighton Grimes, Jianjun Chen, Janet D Rowley, Nancy J Zeleznik-Le

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression

MLL 融合基因 MLL-AF4 调节细胞周期依赖性激酶抑制剂 CDKN1B (p27kip1) 的表达

Zhen-Biao Xia, Relja Popovic, Jing Chen, Catherine Theisler, Tara Stuart, Donna A Santillan, Frank Erfurth, Manuel O Diaz, Nancy J Zeleznik-Le