日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models

线粒体复合物 III 抑制剂阿托伐醌联合抗 PD-L1 疗法对小鼠癌症模型的抗肿瘤作用

Gonzalo Rodriguez-Berriguete, Rathi Puliyadi, Nicole Machado, Alessandro Barberis, Remko Prevo, Martin McLaughlin, Francesca M Buffa, Kevin J Harrington, Geoff S Higgins

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

小分子 Polθ 抑制剂在临床前模型中提供安全有效的肿瘤放射增敏作用

Gonzalo Rodriguez-Berriguete #, Marco Ranzani #, Remko Prevo #, Rathi Puliyadi, Nicole Machado, Hannah R Bolland, Val Millar, Daniel Ebner, Marie Boursier, Aurora Cerutti, Alessandro Cicconi, Alessandro Galbiati, Diego Grande, Vera Grinkevich, Jayesh B Majithiya, Desiree Piscitello, Eeson Rajendra, 

Automated 96-well format high throughput colony formation assay for siRNA library screen

用于 siRNA 文库筛选的自动化 96 孔高通量菌落形成试验

Stephanie B Hatch, Remko Prevo, Tiffany Chan, Val Millar, Bart Cornelissen, Geoff Higgins, Daniel Ebner

Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress

靶向 TOPK 通过增强复制压力使肿瘤细胞对放射诱导损伤敏感

Katharine J Herbert, Rathi Puliyadi, Remko Prevo, Gonzalo Rodriguez-Berriguete, Anderson Ryan, Kristijan Ramadan, Geoff S Higgins

The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress

抗疟药阿托伐醌通过增加氧化应激增强铂介导的癌细胞死亡

James T T Coates, Gonzalo Rodriguez-Berriguete, Rathi Puliyadi, Thomas Ashton, Remko Prevo, Archie Wing, Giovanna Granata, Giacomo Pirovano, Gillies W McKenna, Geoff S Higgins

External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase

外照射放射治疗和 Enadenotucirev:DDR 的抑制和放射介导病毒增加的机制

Tzveta D Pokrovska, Egon J Jacobus, Rathi Puliyadi, Remko Prevo, Sally Frost, Arthur Dyer, Richard Baugh, Gonzalo Rodriguez-Berriguete, Kerry Fisher, Giovanna Granata, Katharine Herbert, William K Taverner, Brian R Champion, Geoff S Higgins, Len W Seymour, Janet Lei-Rossmann

Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy

前列腺癌中 EZH2 表达增加与外照射放射治疗后的转移性复发有关

Xiaoning Wu, Helen Scott, Sigrid V Carlsson, Daniel D Sjoberg, Lucia Cerundolo, Hans Lilja, Remko Prevo, Guillaume Rieunier, Valentine Macaulay, Geoffrey S Higgins, Clare L Verrill, Alastair D Lamb, Vincent T Cunliffe, Chas Bountra, Freddie C Hamdy, Richard J Bryant

CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner

CDK1 抑制以细胞周期依赖的方式使正常细胞对 DNA 损伤敏感

Remko Prevo, Giacomo Pirovano, Rathi Puliyadi, Katharine J Herbert, Gonzalo Rodriguez-Berriguete, Alice O'Docherty, William Greaves, W Gillies McKenna, Geoff S Higgins

TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy

TOPK 调节肿瘤特异性放射敏感性并与前列腺放射治疗后的复发相关

Giacomo Pirovano, Thomas M Ashton, Katharine J Herbert, Richard J Bryant, Clare L Verrill, Lucia Cerundolo, Francesca M Buffa, Remko Prevo, Iona Harrap, Anderson J Ryan, Valentine Macaulay, William G McKenna, Geoff S Higgins

Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen

使用高通量菌落形成筛选鉴定维生素 B1 代谢为肿瘤特异性放射增敏途径

Gaganpreet S Tiwana, Remko Prevo, Francesca M Buffa, Sheng Yu, Daniel V Ebner, Alison Howarth, Lisa K Folkes, Balam Budwal, Kwun-Ye Chu, Lisa Durrant, Ruth J Muschel, W Gillies McKenna, Geoff S Higgins