日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo

发现 AVI-6451,一种强效且选择性的 SARS-CoV-2 ADP-核糖水解酶 Mac1 抑制剂,具有体内口服疗效

Jaishankar, Priyadarshini; Correy, Galen J; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M; Stevens, Maisie G V; Hantz, Eric R; Zheng, Jeffrey; Diolaiti, Morgan E; Montano, Mauricio; Taha, Taha Y; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J; Shoichet, Brian K; Ashworth, Alan; Ott, Melanie; Fraser, James S; Renslo, Adam R

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Structure-Based Design of Reversible, Quinoline-2(1H)‑one Inhibitors of Serine- and Metallo-Carbapenemases

基于结构的可逆喹啉-2(1H)-酮类丝氨酸和金属碳青霉烯酶抑制剂的设计

Jacobs, Lian M C; Jaishankar, Priyadarshini; Zheng, Jeffrey; Hantz, Eric R; Lee, Isabel; Narramneni, Krishna; Poore, Nicholas; Torres, Nathanial; Jackson, Jessica K; Williams, Oriana; Darch, Sophie E; Shaw, Lindsey N; Chen, Yu; Renslo, Adam R

Labile iron pool dynamics do not drive ferroptosis in colorectal cancer cells

不稳定的铁池动态变化并不驱动结直肠癌细胞发生铁死亡。

Ponnusamy, Varun; Randall, Deahzana R; Lee, Zheng Hong; Das, Nupur K; Zhao, Liang; Buscher, Kathryn; Solanki, Sumeet; Renslo, Adam R; Hsu, Peggy P; Shah, Yatrik M

Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

在青蒿素部分耐药性的背景下,寻找下一代抗疟疾三氧杂环戊烷类药物。

Klope, Matthew T; Talukder, Poulami; Blank, Brian R; Chelebieva, Sevil; Chen, Jun; Fontaine, Shaun D; Gonciarz, Ryan L; Jaishankar, Priyadarshini; Lee, Grace J; Legac, Jennifer; Mathur, Vineet; Narayan, Avani; Okitwi, Martin; Orena, Stephen; Settineri, Nicholas S; Tapia, Juan A; Taremwa, Yoweri; Tumwebaze, Patrick K; Vinod, Aswathy; Burrows, Jeremy N; Rosenthal, Philip J; Cooper, Roland A; Renslo, Adam R

Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning.

基于形状片段连接和主动学习探索 SARS-CoV-2 宏结构域的结构-活性关系

Correy Galen J, Rachman Moira M, Togo Takaya, Gahbauer Stefan, Doruk Yagmur U, Stevens Maisie G V, Jaishankar Priyadarshini, Kelley Brian, Goldman Brian, Schmidt Molly, Kramer Trevor, Radchenko Dmytro S, Moroz Yurii S, Ashworth Alan, Riley Patrick, Shoichet Brian K, Renslo Adam R, Walters W Patrick, Fraser James S

Expanding automated multiconformer ligand modeling to macrocycles and fragments

将自动化多构象配体建模扩展到大环化合物和片段

Flowers, Jessica; Echols, Nathaniel; Correy, Galen J; Jaishankar, Priyadarshini; Togo, Takaya; Renslo, Adam R; van den Bedem, Henry; Fraser, James S; Wankowicz, Stephanie A

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens

对 557 个 Mac1-配体复合物和三个虚拟筛选进行大规模前瞻性共折叠评估

Kim, Jongbin; Correy, Galen J; Hall, Brendan W; Rachman, Moira M; Mailhot, Olivier; Togo, Takaya; Gonciarz, Ryan L; Jaishankar, Priyadarshini; Neitz, R Jeffrey; Hantz, Eric R; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Reid, Rashad; Gopalkrishnan, Saumya; Krogan, Nevan J; Renslo, Adam R; Ashworth, Alan; Shoichet, Brian K; Fraser, James S

Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments

将自动化多构象配体建模扩展到大环化合物和片段

Flowers, Jessica; Echols, Nathaniel; Correy, Galen; Jaishankar, Priya; Togo, Takaya; Renslo, Adam R; van den Bedem, Henry; Fraser, James S; Wankowicz, Stephanie A