日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Covalent inhibition of pro-apoptotic BAX.

共价抑制促凋亡蛋白BAX

McHenry Matthew W, Shi Peiwen, Camara Christina M, Cohen Daniel T, Rettenmaier T Justin, Adhikary Utsarga, Gygi Micah A, Yang Ka, Gygi Steven P, Wales Thomas E, Engen John R, Wells James A, Walensky Loren D

Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.

通过二硫键连接鉴定抗凋亡蛋白BFL-1的共价分子抑制剂

Harvey Edward P, Hauseman Zachary J, Cohen Daniel T, Rettenmaier T Justin, Lee Susan, Huhn Annissa J, Wales Thomas E, Seo Hyuk-Soo, Luccarelli James, Newman Catherine E, Guerra Rachel M, Bird Gregory H, Dhe-Paganon Sirano, Engen John R, Wells James A, Walensky Loren D

Redox priming promotes Aurora A activation during mitosis.

氧化还原预处理促进有丝分裂期间 Aurora A 的激活

Lim Daniel C, Joukov Vladimir, Rettenmaier T Justin, Kumagai Akiko, Dunphy William G, Wells James A, Yaffe Michael B

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

通过多温度晶体学、片段筛选和共价连接,揭示了PTP1B中扩展的变构网络

Keedy, Daniel A; Hill, Zachary B; Biel, Justin T; Kang, Emily; Rettenmaier, T Justin; Brandão-Neto, José; Pearce, Nicholas M; von Delft, Frank; Wells, James A; Fraser, James S

Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking

基于结构对接的蛋白激酶PDK1小分子变构调节剂

Rettenmaier, T Justin; Fan, Hao; Karpiak, Joel; Doak, Allison; Sali, Andrej; Shoichet, Brian K; Wells, James A

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

一种模拟肽对接基序的小分子可抑制蛋白激酶PDK1。

Rettenmaier, T Justin; Sadowsky, Jack D; Thomsen, Nathan D; Chen, Steven C; Doak, Allison K; Arkin, Michelle R; Wells, James A

FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions

FP Tethering:一种快速筛选破坏蛋白质-蛋白质相互作用的化合物的技术

Lodge, Jean M; Rettenmaier, T Justin; Wells, James A; Pomerantz, William C; Mapp, Anna K