日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

从头设计靶向土拉弗朗西斯菌毒力因子的高亲和力微型蛋白结合剂

Gokce-Alpkilic, Gizem; Huang, Buwei; Liu, Andi; Kreuk, Lieselotte S M; Wang, Yaxi; Adebomi, Victor; Bueso, Yensi Flores; Bera, Asim K; Kang, Alex; Gerben, Stacey R; Rettie, Stephen; Vafeados, Dionne K; Roullier, Nicole; Goreshnik, Inna; Li, Xinting; Baker, David; Woodward, Joshua J; Mougous, Joseph D; Bhardwaj, Gaurav

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

利用深度学习进行高亲和力蛋白质结合大环化合物的精确从头设计

Rettie, Stephen A; Juergens, David; Adebomi, Victor; Bueso, Yensi Flores; Zhao, Qinqin; Leveille, Alexandria N; Liu, Andi; Bera, Asim K; Wilms, Joana A; Üffing, Alina; Kang, Alex; Brackenbrough, Evans; Lamb, Mila; Gerben, Stacey R; Murray, Analisa; Levine, Paul M; Schneider, Maika; Vasireddy, Vibha; Ovchinnikov, Sergey; Weiergräber, Oliver H; Willbold, Dieter; Kritzer, Joshua A; Mougous, Joseph D; Baker, David; DiMaio, Frank; Bhardwaj, Gaurav

De novo design of high-affinity miniprotein binders targeting Francisella tularensis virulence factor.

从头设计针对土拉弗朗西斯菌毒力因子的高亲和力小蛋白结合剂

Gokce-Alpkilic Gizem, Huang Buwei, Liu Andi, Kreuk Lieselotte S M, Wang Yaxi, Adebomi Victor, Bueso Yensi Flores, Bera Asim K, Kang Alex, Gerben Stacey R, Rettie Stephen, Vafeados Dionne K, Roullier Nicole, Goreshnik Inna, Li Xinting, Baker David, Woodward Joshua J, Mougous Joseph D, Bhardwaj Gaurav

Accurate de novo design of high-affinity protein binding macrocycles using deep learning

利用深度学习进行高亲和力蛋白质结合大环化合物的精确从头设计

Rettie, Stephen A; Juergens, David; Adebomi, Victor; Bueso, Yensi Flores; Zhao, Qinqin; Leveille, Alexandria N; Liu, Andi; Bera, Asim K; Wilms, Joana A; Üffing, Alina; Kang, Alex; Brackenbrough, Evans; Lamb, Mila; Gerben, Stacey R; Murray, Analisa; Levine, Paul M; Schneider, Maika; Vasireddy, Vibha; Ovchinnikov, Sergey; Weiergräber, Oliver H; Willbold, Dieter; Kritzer, Joshua A; Mougous, Joseph D; Baker, David; DiMaio, Frank; Bhardwaj, Gaurav

Cyclic peptide structure prediction and design using AlphaFold

利用AlphaFold进行环肽结构预测和设计

Rettie, Stephen A; Campbell, Katelyn V; Bera, Asim K; Kang, Alex; Kozlov, Simon; De La Cruz, Joshmyn; Adebomi, Victor; Zhou, Guangfeng; DiMaio, Frank; Ovchinnikov, Sergey; Bhardwaj, Gaurav

Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

锚定延伸:一种以结构为导向的环肽设计方法,靶向酶活性位点

Hosseinzadeh, Parisa; Watson, Paris R; Craven, Timothy W; Li, Xinting; Rettie, Stephen; Pardo-Avila, Fátima; Bera, Asim K; Mulligan, Vikram Khipple; Lu, Peilong; Ford, Alexander S; Weitzner, Brian D; Stewart, Lance J; Moyer, Adam P; Di Piazza, Maddalena; Whalen, Joshua G; Greisen, Per Jr; Christianson, David W; Baker, David

Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides

胞质表达、溶液结构和基因编码的富含二硫键的从头设计肽的分子动力学模拟

Buchko, Garry W; Pulavarti, Surya V S R K; Ovchinnikov, Victor; Shaw, Elizabeth A; Rettie, Stephen A; Myler, Peter J; Karplus, Martin; Szyperski, Thomas; Baker, David; Bahl, Christopher D

Comprehensive computational design of ordered peptide macrocycles

有序肽大环的综合计算设计

Hosseinzadeh, Parisa; Bhardwaj, Gaurav; Mulligan, Vikram Khipple; Shortridge, Matthew D; Craven, Timothy W; Pardo-Avila, Fátima; Rettie, Stephen A; Kim, David E; Silva, Daniel-Adriano; Ibrahim, Yehia M; Webb, Ian K; Cort, John R; Adkins, Joshua N; Varani, Gabriele; Baker, David

Accurate de novo design of hyperstable constrained peptides

精确地从头设计超稳定约束肽

Bhardwaj, Gaurav; Mulligan, Vikram Khipple; Bahl, Christopher D; Gilmore, Jason M; Harvey, Peta J; Cheneval, Olivier; Buchko, Garry W; Pulavarti, Surya V S R K; Kaas, Quentin; Eletsky, Alexander; Huang, Po-Ssu; Johnsen, William A; Greisen, Per Jr; Rocklin, Gabriel J; Song, Yifan; Linsky, Thomas W; Watkins, Andrew; Rettie, Stephen A; Xu, Xianzhong; Carter, Lauren P; Bonneau, Richard; Olson, James M; Coutsias, Evangelos; Correnti, Colin E; Szyperski, Thomas; Craik, David J; Baker, David