SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8(+) T cells
SHP2通过抑制CD8(+) T细胞中SKP2靶向的TBET泛素化作用,促进结节病病情加重。
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.ade2581
Celada, Sherly I; Lim, Clarice X; Carisey, Alexandre F; Ochsner, Scott A; Arce Deza, Carlos F; Rexie, Praveen; Poli De Frias, Fernando; Cardenas-Castillo, Rafael; Polverino, Francesca; Hengstschläger, Markus; Tsoyi, Konstantin; McKenna, Neil J; Kheradmand, Farrah; Weichhart, Thomas; Rosas, Ivan O; Van Kaer, Luc; Celada, Lindsay J
表观遗传
T细胞
泛素化
CD8
T细胞
细胞生物学
免疫/内分泌