日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors.

对强效且高选择性的 CDK2 抑制剂 BLU-222 的活性进行分析,揭示了 CCNE1 异常卵巢和子宫内膜肿瘤的反应决定因素

House Nealia C, Brown Victoria E, Chen Maxine, Yuan Liang, Moore Sydney L, Guo Jian, Choi Yoon Jong, Muthuswamy Lakshmi, Ribich Scott, Ramsden Philip, Faia Kerrie L

Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现:一种口服有效的 DHX9 变构抑制剂

Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann

Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020:硅原子取代的战术应用

Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W

CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination

CDK2 通过同源重组调控 CCNE1 扩增的卵巢癌细胞中复制叉修复的崩溃

Victoria E Brown, Sydney L Moore, Maxine Chen, Nealia House, Philip Ramsden, Hsin-Jung Wu, Scott Ribich, Alexandra R Grassian, Yoon Jong Choi

EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL

他泽司他抑制 EZH2 导致 DLBCL 对 B 细胞活化信号的依赖性改变

Dorothy Brach, Danielle Johnston-Blackwell, Allison Drew, Trupti Lingaraj, Vinny Motwani, Natalie M Warholic, Igor Feldman, Christopher Plescia, Jesse J Smith, Robert A Copeland, Heike Keilhack, Elayne Chan-Penebre, Sarah K Knutson, Scott A Ribich, Alejandra Raimondi, Michael J Thomenius

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models

通过抑制 EZH2 选择性杀死 SMARCA2 和 SMARCA4 缺陷型卵巢小细胞癌、高钙血症型细胞:体外和体内临床前模型

Elayne Chan-Penebre, Kelli Armstrong, Allison Drew, Alexandra R Grassian, Igor Feldman, Sarah K Knutson, Kristy Kuplast-Barr, Maria Roche, John Campbell, Peter Ho, Robert A Copeland, Richard Chesworth, Jesse J Smith, Heike Keilhack, Scott A Ribich

Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

EZH2 抑制在人类滑膜肉瘤模型中诱导抗肿瘤活性的临床前证据

Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M Pollock, Jesse S Smith, Kevin K Kuntz, Scott Ribich, Yukinori Minoshima, Junji Matsui, Robert A Copeland, Shinya Tanaka, Heike Keilhack

A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality

中通量单细胞 CRISPR-Cas9 检测以评估基因必需性

A R Grassian #, T M E Scales #, S K Knutson, K W Kuntz, N J McCarthy, C E Lowe, J D Moore, R A Copeland, H Keilhack, J J Smith, J A Wickenden, S Ribich

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

化学伴侣牛磺熊去氧胆酸和4-苯基丁酸可加速甲状腺激素活化和能量消耗。

da-Silva, Wagner S; Ribich, Scott; Arrojo e Drigo, Rafael; Castillo, Melany; Patti, Mary-Elizabeth; Bianco, Antonio C