日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors.

对强效且高选择性的 CDK2 抑制剂 BLU-222 的活性进行分析,揭示了 CCNE1 异常卵巢和子宫内膜肿瘤的反应决定因素

House Nealia C, Brown Victoria E, Chen Maxine, Yuan Liang, Moore Sydney L, Guo Jian, Choi Yoon Jong, Muthuswamy Lakshmi, Ribich Scott, Ramsden Philip, Faia Kerrie L

Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现:一种口服有效的 DHX9 变构抑制剂

Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann

Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020:硅原子取代的战术应用

Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

化学伴侣牛磺熊去氧胆酸和4-苯基丁酸可加速甲状腺激素活化和能量消耗。

da-Silva, Wagner S; Ribich, Scott; Arrojo e Drigo, Rafael; Castillo, Melany; Patti, Mary-Elizabeth; Bianco, Antonio C

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

SIRT1同源物在禁食依赖性脂质/胆固醇调节因子SREBP抑制中发挥保守作用

Walker, Amy K; Yang, Fajun; Jiang, Karen; Ji, Jun-Yuan; Watts, Jennifer L; Purushotham, Aparna; Boss, Olivier; Hirsch, Michael L; Ribich, Scott; Smith, Jesse J; Israelian, Kristine; Westphal, Christoph H; Rodgers, Joseph T; Shioda, Toshi; Elson, Sarah L; Mulligan, Peter; Najafi-Shoushtari, Hani; Black, Josh C; Thakur, Jitendra K; Kadyk, Lisa C; Whetstine, Johnathan R; Mostoslavsky, Raul; Puigserver, Pere; Li, Xiaoling; Dyson, Nicholas J; Hart, Anne C; Näär, Anders M

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling

脱碘酶调控甲状腺激素信号的细胞和分子基础

Gereben, Balázs; Zavacki, Ann Marie; Ribich, Scott; Kim, Brian W; Huang, Stephen A; Simonides, Warner S; Zeöld, Anikó; Bianco, Antonio C