日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia

靶向 LMO2 诱导的自分泌 FLT3 信号以克服早期 T 细胞前体急性淋巴细胞白血病的化学耐药性

Cedric S Tremblay, Jesslyn Saw, Feng Yan, Jacqueline A Boyle, Ovini Amarasinghe, Shokoufeh Abdollahi, Anh N Q Vo, Benjamin J Shields, Chelsea Mayoh, Hannah McCalmont, Kathryn Evans, Anna Steiner, Kevin Parsons, Matthew P McCormack, David R Powell, Nicholas C Wong, Stephen M Jane, Richard B Lock, Dav

FDA-approved disulfiram as a novel treatment for aggressive leukemia

FDA 批准双硫仑作为治疗侵袭性白血病的新方法

Mawar Karsa, Lin Xiao, Emma Ronca, Angelika Bongers, Dayna Spurling, Ayu Karsa, Sandra Cantilena, Anna Mariana, Tim W Failes, Greg M Arndt, Laurence C Cheung, Rishi S Kotecha, Rosemary Sutton, Richard B Lock, Owen Williams, Jasper de Boer, Michelle Haber, Murray D Norris, Michelle J Henderson, Klaar

PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia

PLK1 作为 BCL2 介导的白血病抗凋亡程序的合作伙伴

Kinjal Shah, Ahmad Nasimian, Mehreen Ahmed, Lina Al Ashiri, Linn Denison, Wondossen Sime, Katerina Bendak, Iryna Kolosenko, Valentina Siino, Fredrik Levander, Caroline Palm-Apergi, Ramin Massoumi, Richard B Lock, Julhash U Kazi

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

Curaxin CBL0137 与组蛋白去乙酰化酶抑制剂 Panobinostat 联合使用可延缓 KMT2A 重排白血病进展

Lin Xiao, Mawar Karsa, Emma Ronca, Angelika Bongers, Angelika Kosciolek, Ali El-Ayoubi, Jezrael L Revalde, Janith A Seneviratne, Belamy B Cheung, Laurence C Cheung, Rishi S Kotecha, Andrea Newbold, Stefan Bjelosevic, Greg M Arndt, Richard B Lock, Ricky W Johnstone, Andrei V Gudkov, Katerina V Gurova

Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin

通过金诺芬利用高风险儿童急性淋巴细胞白血病中的活性氧失衡

Mawar Karsa, Angelika Kosciolek, Angelika Bongers, Anna Mariana, Tim Failes, Andrew J Gifford, Ursula R Kees, Laurence C Cheung, Rishi S Kotecha, Greg M Arndt, Michelle Haber, Murray D Norris, Rosemary Sutton, Richard B Lock, Michelle J Henderson #, Klaartje Somers #

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells

小分子抑制动力蛋白依赖性内吞作用靶向多个微环境信号并损害白血病干细胞

Cedric S Tremblay, Sung Kai Chiu, Jesslyn Saw, Hannah McCalmont, Veronique Litalien, Jacqueline Boyle, Stefan E Sonderegger, Ngoc Chau, Kathryn Evans, Loretta Cerruti, Jessica M Salmon, Adam McCluskey, Richard B Lock, Phillip J Robinson, Stephen M Jane, David J Curtis

PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis

PIM激酶抑制剂阻断原发性T细胞急性淋巴细胞白血病的生长:网络建模分析揭示耐药通路

James T Lim ,Neha Singh ,Libia A Leuvano ,Valerie S Calvert ,Emanuel F Petricoin ,David T Teachey ,Richard B Lock ,Megha Padi ,Andrew S Kraft ,Sathish K R Padi

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

Menin-MLL抑制剂可诱导特定的染色质改变,并在MLL重排白血病模型中根除疾病。

Andrei V Krivtsov,Kathryn Evans,Jayant Y Gadrey,Benjamin K Eschle,Charlie Hatton,Hannah J Uckelmann,Kenneth N Ross,Florian Perner,Sarah N Olsen,Tara Pritchard,Lisa McDermott,Connor D Jones,Duohui Jing,Ali Braytee,Diego Chacon,Eric Earley,Brian M McKeever,David Claremon,Andrew J Gifford,Heather J Lee,Beverly A Teicher,John E Pimanda,Dominik Beck,Jennifer A Perry,Malcolm A Smith,Gerard M McGeehan,Richard B Lock,Scott A Armstrong

Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia

罗米地辛可增强阿糖胞苷的体内疗效,表明组蛋白去乙酰化酶抑制是治疗 KMT2A 重排婴儿急性淋巴细胞白血病的一种有希望的治疗策略

Laurence C Cheung, Mark N Cruickshank, Anastasia M Hughes, Sajla Singh, Grace-Alyssa Chua, Jette Ford, Emanuela Ferrari, Joyce Oommen, Sébastien Malinge, Richard B Lock, Ursula R Kees, Rishi S Kotecha

Thiol-Reactive Star Polymers Functionalized with Short Ethoxy-Containing Moieties Exhibit Enhanced Uptake in Acute Lymphoblastic Leukemia Cells

用短乙氧基部分功能化的硫醇反应性星形聚合物在急性淋巴细胞白血病细胞中表现出增强的摄取

Narges Bayat, Nathan McOrist, Nicholas Ariotti, May Lai, Keith Cs Sia, Yuhuan Li, James L Grace, John F Quinn, Michael R Whittaker, Maria Kavallaris, Thomas P Davis #, Richard B Lock #