日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression

肌张力障碍基因 THAP1 的功能丧失突变通过抑制 PSMB5 表达损害蛋白酶体功能

Dylan E Ramage, Drew W Grant, Richard T Timms

Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase

CRL2FEM1B 泛素连接酶识别 Ψ-Pro/C-degron 的机制

Xinyan Chen # ,Anat Raiff # ,Shanshan Li ,Qiong Guo ,Jiahai Zhang ,Hualin Zhou ,Richard T Timms ,Xuebiao Yao ,Stephen J Elledge ,Itay Koren ,Kaiming Zhang ,Chao Xu

Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability

N-降解途径的二肽基肽酶和 E3 连接酶协同调节蛋白质稳定性

Adi Shimshon #, Karin Dahan #, Mor Israel-Gueta #, Diana Olmayev-Yaakobov #, Richard T Timms #, Aizat Bekturova, Yaara Makaros, Stephen J Elledge, Itay Koren

Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses

种系编码的氨基酸结合基序驱动免疫显性公共抗体反应

Ellen L Shrock, Richard T Timms #, Tomasz Kula #, Elijah L Mena, Anthony P West Jr, Rui Guo, I-Hsiu Lee, Alexander A Cohen, Lindsay G A McKay, Caihong Bi, Yumei Leng, Eric Fujimura, Felix Horns, Mamie Li, Duane R Wesemann, Anthony Griffiths, Benjamin E Gewurz, Pamela J Bjorkman, Stephen J Elledge

High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform

利用功能遗传筛选平台进行高通量、靶向的MHC I类免疫肽组学分析

Peter M Bruno ,Richard T Timms ,Nouran S Abdelfattah ,Yumei Leng ,Felipe J N Lelis ,Duane R Wesemann ,Xu G Yu ,Stephen J Elledge

Defining E3 ligase-substrate relationships through multiplex CRISPR screening

通过多重 CRISPR 筛选确定 E3 连接酶-底物关系

Richard T Timms #, Elijah L Mena #, Yumei Leng, Mamie Z Li, Iva A Tchasovnikarova, Itay Koren, Stephen J Elledge

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping

通过蛋白质组内部降解物映射阐明 E3 泛素连接酶特异性

Zhiqian Zhang, Brandon Sie, Aiquan Chang, Yumei Leng, Christopher Nardone, Richard T Timms, Stephen J Elledge

Ubiquitin-independent proteasomal degradation driven by C-degron pathways

由 C-降解途径驱动的不依赖泛素的蛋白酶体降解

Yaara Makaros, Anat Raiff, Richard T Timms, Ajay R Wagh, Mor Israel Gueta, Aizat Bekturova, Julia Guez-Haddad, Sagie Brodsky, Yarden Opatowsky, Michael H Glickman, Stephen J Elledge, Itay Koren

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

营养物质对 TFE3 和 MITF 的控制中,调节蛋白质稳定性的核心作用

Christopher Nardone, Brad A Palanski, Daniel C Scott, Richard T Timms, Karl W Barber, Xin Gu, Aoyue Mao, Yumei Leng, Emma V Watson, Brenda A Schulman, Philip A Cole, Stephen J Elledge

Systematic characterization of mutations altering protein degradation in human cancers

对人类癌症中改变蛋白质降解的突变进行系统性表征

Collin Tokheim ,Xiaoqing Wang ,Richard T Timms ,Boning Zhang ,Elijah L Mena ,Binbin Wang ,Cynthia Chen ,Jun Ge ,Jun Chu ,Wubing Zhang ,Stephen J Elledge ,Myles Brown ,X Shirley Liu