日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Balancing the efficacy and safety of chimeric antigen receptor T-cell therapy by affinity combination

通过亲和力组合平衡嵌合抗原受体T细胞疗法的疗效和安全性

Warmuth, Linda; Dötsch, Sarah; Trebo, Manuel; Bellucci, Sarah; Engels, Sophia; Valdivia Manrique, Rafael; Moukarzel, Karl; Schütz, Julius M; Hammel, Monika; Straub, Adrian; Wagner, Sabrina; Hochholzer, Anna; Salinno, Ciro; Seigner, Jacqueline; Zajc, Charlotte U; Schmidt, Georg P; Michael, Josefine; Nerreter, Thomas; Hudecek, Michael; Traxlmayr, Michael W; Casucci, Monica; Riddell, Stanley R; Poltorak, Mateusz P; Busch, Dirk H; D'Ippolito, Elvira

A phase 1 trial of fully human BCMA CAR-T therapy for relapsed/refractory multiple myeloma with 5-year follow-up

一项针对复发/难治性多发性骨髓瘤的全人源BCMA CAR-T疗法的I期临床试验,随访时间为5年。

Tuazon, Sherilyn A; Portuguese, Andrew J; Pont, Margot J; Cowan, Andrew J; Cole, Gabriel O; Sather, Blythe D; Song, Xiaoling; Thomas, Sushma; Wood, Brent L; Blake, Michelle; Works, Melissa G; Shadman, Mazyar; Liang, Emily C; Wu, Qian V; Voutsinas, Jenna M; Gooley, Ted A; Turtle, Cameron J; Till, Brian G; Coffey, David G; Maloney, David G; Riddell, Stanley R; Green, Damian J

Single-cell analysis of the multiple myeloma microenvironment after γ-secretase inhibition and CAR T-cell therapy

γ-分泌酶抑制剂和CAR T细胞疗法后多发性骨髓瘤微环境的单细胞分析

Coffey, David G; Ataca Atilla, Pinar; Atilla, Erden; Landgren, Ola; Cowan, Andrew J; Simon, Sylvain; Pont, Margot J; Comstock, Melissa L; Hill, Geoffrey R; Riddell, Stanley R; Green, Damian J

Phase 1 study of CD19 CAR T-cell therapy harboring a fully human scFv in CAR-naïve adult patients with B-ALL

一项针对初治成人B细胞急性淋巴细胞白血病患者的CD19 CAR T细胞疗法(携带全人源scFv)的I期研究

Gauthier, Jordan; Liang, Emily C; Huang, Jennifer J; Kimble, Erik L; Hirayama, Alexandre V; Fiorenza, Salvatore; Voutsinas, Jenna M; Wu, Qian Vicky; Jaeger-Ruckstuhl, Carla A; Pender, Barbara S; Kirchmeier, Delaney R; Torkelson, Aiko; Braathen, Kristina; Basom, Ryan; Shadman, Mazyar; Kopmar, Noam E; Cassaday, Ryan D; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J

Quantifying HLA transcripts by genotype in chimeric mixtures at single-cell resolution

在单细胞分辨率下,通过基因型对嵌合混合物中的HLA转录本进行定量

Kanaan, Sami B; Underwood, Jason G; Gladden, Rula Green; Fan, Everett; Bhise, Shruti S; Thakar, Monica S; Jaeger-Ruckstuhl, Carla A; Stevens, Jeffrey; Gray, Ashley N; Riddell, Stanley R; Bleakley, Marie; Meshinchi, Soheil; Furlan, Scott N

HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation

HA-1靶向T细胞受体T细胞疗法治疗造血干细胞移植后复发性白血病

Krakow, Elizabeth F; Brault, Michelle; Summers, Corinne; Cunningham, Tanya M; Biernacki, Melinda A; Black, R Graeme; Woodward, Kyle B; Vartanian, Nicole; Kanaan, Sami B; Yeh, Albert C; Dossa, Robson G; Bar, Merav; Cassaday, Ryan D; Dahlberg, Ann; Till, Brian G; Denker, Andrew E; Yeung, Cecilia C S; Gooley, Ted A; Maloney, David G; Riddell, Stanley R; Greenberg, Philip D; Chapuis, Aude G; Newell, Evan W; Furlan, Scott N; Bleakley, Marie

CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target

CBFA2T3-GLIS2 儿童急性巨核细胞白血病模型鉴定出 FOLR1 为 CAR T 细胞靶点

Le, Quy; Hadland, Brandon; Smith, Jenny L; Leonti, Amanda; Huang, Benjamin J; Ries, Rhonda; Hylkema, Tiffany A; Castro, Sommer; Tang, Thao T; McKay, Cyd N; Perkins, LaKeisha; Pardo, Laura; Sarthy, Jay; Beckman, Amy K; Williams, Robin; Idemmili, Rhonda; Furlan, Scott; Ishida, Takashi; Call, Lindsey; Srivastava, Shivani; Loeb, Anisha M; Milano, Filippo; Imren, Suzan; Morris, Shelli M; Pakiam, Fiona; Olson, Jim M; Loken, Michael R; Brodersen, Lisa; Riddell, Stanley R; Tarlock, Katherine; Bernstein, Irwin D; Loeb, Keith R; Meshinchi, Soheil

Timing of anti-PD-L1 antibody initiation affects efficacy/toxicity of CD19 CAR T-cell therapy for large B-cell lymphoma

抗PD-L1抗体启动治疗的时机影响CD19 CAR T细胞疗法治疗大B细胞淋巴瘤的疗效/毒性。

Hirayama, Alexandre V; Kimble, Erik L; Wright, Jocelyn H; Fiorenza, Salvatore; Gauthier, Jordan; Voutsinas, Jenna M; Wu, Qian; Yeung, Cecilia C S; Gazeau, Nicolas; Pender, Barbara S; Kirchmeier, Delaney R; Torkelson, Aiko; Chutnik, Abigail N; Cassaday, Ryan D; Chapuis, Aude G; Green, Damian J; Kiem, Hans-Peter; Milano, Filippo; Shadman, Mazyar; Till, Brian G; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

克服CAR-T细胞疗法治疗实体瘤的靶向毒性和脱靶毒性

Flugel, Christian L; Majzner, Robbie G; Krenciute, Giedre; Dotti, Gianpietro; Riddell, Stanley R; Wagner, Dimitrios L; Abou-El-Enein, Mohamed

γ-Secretase inhibitor in combination with BCMA chimeric antigen receptor T-cell immunotherapy for individuals with relapsed or refractory multiple myeloma: a phase 1, first-in-human trial

γ-分泌酶抑制剂联合BCMA嵌合抗原受体T细胞免疫疗法治疗复发或难治性多发性骨髓瘤患者:一项I期首次人体试验

Cowan, Andrew J; Pont, Margot J; Sather, Blythe D; Turtle, Cameron J; Till, Brian G; Libby, Edward N 3rd; Coffey, David G; Tuazon, Sherilyn A; Wood, Brent; Gooley, Ted; Wu, Vicky Q; Voutsinas, Jenna; Song, Xiaoling; Shadman, Mazyar; Gauthier, Jordan; Chapuis, Aude G; Milano, Filippo; Maloney, David G; Riddell, Stanley R; Green, Damian J