Rienk Offringa相关文献与解析，生知库 | 链接生命科学的每一步

Vera Thiel #,Simon Renders #,Jasper Panten #,Nicolas Dross,Katharina Bauer,Daniel Azorin,Vanessa Henriques,Vanessa Vogel,Corinna Klein,Aino-Maija Leppä,Isabel Barriuso Ortega,Jonas Schwickert,Iordanis Ourailidis,Julian Mochayedi,Jan-Philipp Mallm,Carsten Müller-Tidow,Hannah Monyer,John Neoptolemos,Thilo Hackert,Oliver Stegle,Duncan T Odom,Rienk Offringa,Albrecht Stenzinger,Frank Winkler,Martin Sprick,Andreas Trumpp

胰腺癌

神经科学

肿瘤

发表日期：2025

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Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T-Cell Immunity against Cancer

BAY-405 的发现：一种基于氮杂吲哚的 MAP4K1 抑制剂，可增强 T 细胞对癌症的免疫力

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.4c01325

Jeffrey Mowat ，Rafael Carretero ，Gabriele Leder ，Nuria Aiguabella Font ，Roland Neuhaus ，Sandra Berndt ，Judith Günther ，Anders Friberg ，Martina Schäfer ，Hans Briem ，Marian Raschke ，Hideki Miyatake Ondozabal ，Bernd Buchmann ，Ulf Boemer ，Bertolt Kreft ，Ingo V Hartung ，Rienk Offringa

optiPRM: A Targeted Immunopeptidomics LC-MS Workflow With Ultra-High Sensitivity for the Detection of Mutation-Derived Tumor Neoepitopes From Limited Input Material

optiPRM：一种具有超高灵敏度的靶向免疫肽组学 LC-MS 工作流程，用于从有限的输入材料中检测突变衍生的肿瘤新表位

期刊:Molecular & Cellular Proteomics

影响因子:6.1

doi:10.1016/j.mcpro.2024.100825

Mogjiborahman Salek, Jonas D Förster, Jonas P Becker, Marten Meyer, Pornpimol Charoentong, Yanhong Lyu, Katharina Lindner, Catharina Lotsch, Michael Volkmar, Frank Momburg, Isabel Poschke, Stefan Fröhling, Marc Schmitz, Rienk Offringa, Michael Platten, Dirk Jäger, Inka Zörnig, Angelika B Riemer5

T-Cell-Based Platform for Functional Screening of T-Cell Receptors Identified in Single-Cell RNA Sequencing Data Sets of Tumor-Infiltrating T-Cells

基于T细胞的平台用于对肿瘤浸润T细胞单细胞RNA测序数据集中鉴定的T细胞受体进行功能筛选

期刊:Bio-protocol

影响因子:1

doi:10.21769/BioProtoc.4972

Aaron Rodriguez Ehrenfried ，Stefan Zens ，Laura K Steffens ，Hannes Kehm ，Alina Paul ，Claudia Lauenstein ，Michael Volkmar ，Isabel Poschke ，Zibo Meng ，Rienk Offringa

Identification of TRDV-TRAJ V domains in human and mouse T-cell receptor repertoires

人类和小鼠T细胞受体库中TRDV-TRAJ V结构域的鉴定

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2023.1286688

Michael Volkmar ，Elham Fakhr ，Stefan Zens ，Alice Bury ，Rienk Offringa ，Jessica Gordon ，Enes Huduti ，Thomas Wölfel ，Catherine Wölfel

p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition

M1 巨噬细胞中的 p38 MAPK 信号传导导致 MEK 抑制选择性消除 M2 巨噬细胞

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.3

doi:10.1136/jitc-2020-002319

Daniel Baumann, Jennifer Drebant, Tanja Hägele, Luisa Burger, Clara Serger, Claudia Lauenstein, Przemyslaw Dudys, Gerrit Erdmann, Rienk Offringa

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy

MEK抑制剂的促免疫原性作用与激动剂抗CD40免疫刺激抗体在肿瘤治疗中具有协同作用。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-020-15979-2

Daniel Baumann ，Tanja Hägele ，Julian Mochayedi ，Jennifer Drebant ，Caroline Vent ，Sven Blobner ，Julia Han Noll ，Irena Nickel ，Corinna Schumacher ，Sophie Luise Boos ，Aline Sophie Daniel ，Susann Wendler ，Michael Volkmar ，Oliver Strobel ，Rienk Offringa

Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line

辐射诱导的小鼠胰腺导管腺癌细胞系免疫原性的改变

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-020-57456-2

Philipp Schröter, Laura Hartmann, Wolfram Osen, Daniel Baumann, Rienk Offringa, David Eisel, Jürgen Debus, Stefan B Eichmüller #, Stefan Rieken #

Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines

光子与碳离子辐照：对小鼠肿瘤细胞系的免疫调节作用

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-020-78577-8

Laura Hartmann, Philipp Schröter, Wolfram Osen, Daniel Baumann, Rienk Offringa, Mahmoud Moustafa, Rainer Will, Jürgen Debus, Stephan Brons, Stefan Rieken, Stefan B Eichmüller

Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells

CD2 信号的磷酸化蛋白质组学揭示了 AMPK 依赖的细胞毒性 T 细胞溶解颗粒极化的调节

期刊:Science Signaling

影响因子:

doi:10.1126/scisignal.aaz1965

Vanessa Zurli, Tommaso Montecchi, Raphael Heilig, Isabel Poschke, Michael Volkmar, Giuliana Wimmer, Gioia Boncompagni, Gabriele Turacchio, Mario Milco D'Elios, Giuseppe Campoccia, Nicoletta Resta, Rienk Offringa, Roman Fischer, Oreste Acuto, Cosima Tatiana Baldari, Anna Kabanova

Characterization of single neurons reprogrammed by pancreatic cancer

胰腺癌重编程的单个神经元的特征分析

Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T-Cell Immunity against Cancer

BAY-405 的发现：一种基于氮杂吲哚的 MAP4K1 抑制剂，可增强 T 细胞对癌症的免疫力

optiPRM: A Targeted Immunopeptidomics LC-MS Workflow With Ultra-High Sensitivity for the Detection of Mutation-Derived Tumor Neoepitopes From Limited Input Material

optiPRM：一种具有超高灵敏度的靶向免疫肽组学 LC-MS 工作流程，用于从有限的输入材料中检测突变衍生的肿瘤新表位

T-Cell-Based Platform for Functional Screening of T-Cell Receptors Identified in Single-Cell RNA Sequencing Data Sets of Tumor-Infiltrating T-Cells

基于T细胞的平台用于对肿瘤浸润T细胞单细胞RNA测序数据集中鉴定的T细胞受体进行功能筛选

Identification of TRDV-TRAJ V domains in human and mouse T-cell receptor repertoires

人类和小鼠T细胞受体库中TRDV-TRAJ V结构域的鉴定

p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition

M1 巨噬细胞中的 p38 MAPK 信号传导导致 MEK 抑制选择性消除 M2 巨噬细胞

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy

MEK抑制剂的促免疫原性作用与激动剂抗CD40免疫刺激抗体在肿瘤治疗中具有协同作用。

Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line

辐射诱导的小鼠胰腺导管腺癌细胞系免疫原性的改变

Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines

光子与碳离子辐照：对小鼠肿瘤细胞系的免疫调节作用

Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells

CD2 信号的磷酸化蛋白质组学揭示了 AMPK 依赖的细胞毒性 T 细胞溶解颗粒极化的调节