Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism
选择性口服 ROCK2 抑制剂通过 STAT3 依赖性机制下调人 T 细胞中 IL-21 和 IL-17 的分泌。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1414189111
Zanin-Zhorov, Alexandra; Weiss, Jonathan M; Nyuydzefe, Melanie S; Chen, Wei; Scher, Jose U; Mo, Rigen; Depoil, David; Rao, Nishta; Liu, Ben; Wei, Jianlu; Lucas, Sarah; Koslow, Matthew; Roche, Maria; Schueller, Olivier; Weiss, Sara; Poyurovsky, Masha V; Tonra, James; Hippen, Keli L; Dustin, Michael L; Blazar, Bruce R; Liu, Chuan-ju; Waksal, Samuel D
IL-21
T细胞
IL-17
JAK/STAT
ROCK2
STAT3
ROCK
IL-2
细胞生物学