日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

FAK抑制剂联合RAF-MEK钳制抑制剂avutometinib可克服BRAF V600E黑色素瘤对靶向治疗和免疫疗法的耐药性。

期刊:Cancer Cell
影响因子:48.8
doi:10.1016/j.ccell.2025.02.001
Simone Lubrano，Rodolfo Daniel Cervantes-Villagrana，Farhoud Faraji，Sydney Ramirez，Kuniaki Sato，Sendi R Adame-Garcia，Adam Officer，Nadia Arang，Damiano C Rigiracciolo，Paola Y Anguiano Quiroz，Claudia Martini，YiYu Wang，Fleur M Ferguson，Antonietta Bacchiocchi，Ruth Halaban，Silvia Coma，Sheri L Holmen，Jonathan A Pachter，Andrew E Aplin，J Silvio Gutkind
黑色素瘤
免疫/内分泌
MET
BRAF
FAK
发表日期：2025
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Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis

NUMB 缺失通过 RHOA/ROCK/YAP 信号轴驱动侵袭性膀胱癌

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-54246-6
F A Tucci #, R Pennisi #, D C Rigiracciolo, M G Filippone, R Bonfanti, F Romeo, S Freddi, E Guerrera, C Soriani, S Rodighiero, R H Gunby, G Jodice, F Sanguedolce, G Renne, N Fusco, P P Di Fiore, G Pruneri, G Bertalot, G Musi, G Vago, D Tosoni, S Pece2
肿瘤
膀胱癌
Human
发表日期：2024
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High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

高通量化学遗传药物筛选揭示 PKC-RhoA/PKN 是 GNAQ 驱动的葡萄膜黑色素瘤中可靶向的信号通路脆弱性

期刊:Cell Reports Medicine
影响因子:11.7
doi:10.1016/j.xcrm.2023.101244
Nadia Arang ，Simone Lubrano ，Michele Ceribelli ，Damiano C Rigiracciolo ，Robert Saddawi-Konefka ，Farhoud Faraji ，Sydney I Ramirez ，Daehwan Kim ，Frances A Tosto ，Erica Stevenson ，Yuan Zhou ，Zhiyong Wang ，Julius Bogomolovas ，Alfredo A Molinolo ，Danielle L Swaney ，Nevan J Krogan ，Jing Yang ，Silvia Coma ，Jonathan A Pachter ，Andrew E Aplin ，Dario R Alessi ，Craig J Thomas ，J Silvio Gutkind
黑色素瘤
PKC
信号转导
发表日期：2023
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The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells

Ephrin 酪氨酸激酶 a3 (EphA3) 是 RAGE 促进乳腺癌细胞迁移的新型介质

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-023-02747-5
Marianna Talia #, Francesca Cirillo #, Asia Spinelli #, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elvira Brunelli, Anna Maria Miglietta, Bru
肿瘤
乳腺癌
肿瘤细胞
发表日期：2023
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RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer

RAGE 抑制可减弱乳腺癌中胰岛素诱导的致癌信号

期刊:Breast Cancer Research
影响因子:6.1
doi:10.1186/s13058-023-01686-5
M G Muoio #, M Pellegrino #, V Rapicavoli, M Talia, G Scavo, V Sergi, V Vella, S Pettinato, M G Galasso, R Lappano, D Scordamaglia, F Cirillo, A Pulvirenti, D C Rigiracciolo, M Maggiolini, A Belfiore #, E M De Francesco #
信号转导
肿瘤
乳腺癌
Insulin Receptor
发表日期：2023
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GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway

GPER 缺失通过 JNK/c-Jun/p53/Noxa 转导通路在三阴性乳腺癌 (TNBC) 细胞中引发抑制作用

期刊:Cell Death Discovery
影响因子:6.1
doi:10.1038/s41420-023-01654-0
Francesca Cirillo #, Marianna Talia #, Maria Francesca Santolla #, Michele Pellegrino #, Domenica Scordamaglia, Asia Spinelli, Salvatore De Rosis, Francesca Giordano, Lucia Muglia, Azzurra Zicarelli, Marika Di Dio, Damiano Cosimo Rigiracciolo, Anna Maria Miglietta, Gianfranco Filippelli, Ernestina M
信号转导
肿瘤
乳腺癌
其它细胞
发表日期：2023
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Publisher Correction: RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer

出版商更正：RAGE抑制剂可减弱乳腺癌中胰岛素诱导的致癌信号

期刊:Breast Cancer Research
影响因子:5.6
doi:10.1186/s13058-023-01689-2
Muoio, M G; Pellegrino, M; Rapicavoli, V; Talia, M; Scavo, G; Sergi, V; Vella, V; Pettinato, S; Galasso, M G; Lappano, R; Scordamaglia, D; Cirillo, F; Pulvirenti, A; Rigiracciolo, D C; Maggiolini, M; Belfiore, A; De Francesco, E M
肿瘤
肿瘤免疫
信号转导
乳腺癌
RAGE
免疫/内分泌
发表日期：2023
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Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry

全基因组 CRISPR 筛选确定 PI3K/AKT 是致癌 GNAQ-粘着斑激酶信号通路的下游成分

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1016/j.jbc.2022.102866
Nadia Arang, Simone Lubrano, Damiano Cosimo Rigiracciolo, Daniela Nachmanson, Scott M Lippman, Prashant Mali, Olivier Harismendy, J Silvio Gutkind
信号转导
肿瘤
Adhesion/ECM
PI3K/Akt
发表日期：2023
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Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)

粘着斑激酶 (FAK)-Hippo/YAP 转导信号介导 S100A8/A9-RAGE 系统在三阴性乳腺癌 (TNBC) 中发挥的刺激作用

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-022-02396-0
Damiano Cosimo Rigiracciolo, Nijiro Nohata, Rosamaria Lappano, Francesca Cirillo, Marianna Talia, Sendi Rafael Adame-Garcia, Nadia Arang, Simone Lubrano, Ernestina Marianna De Francesco, Antonino Belfiore, J Silvio Gutkind, Marcello Maggiolini
信号转导
肿瘤
乳腺癌
WB
Adhesion/ECM
Hippo
发表日期：2022
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Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells

二甲双胍抵消胰岛素对原发性乳腺癌细胞的刺激作用

期刊:Journal of Translational Medicine
影响因子:6.1
doi:10.1186/s12967-022-03463-y
Domenica Scordamaglia #, Francesca Cirillo #, Marianna Talia #, Maria Francesca Santolla, Damiano Cosimo Rigiracciolo, Lucia Muglia, Azzurra Zicarelli, Salvatore De Rosis, Francesca Giordano, Anna Maria Miglietta, Ernestina Marianna De Francesco, Veronica Vella, Antonino Belfiore, Rosamaria Lappano,
肿瘤
乳腺癌
肿瘤细胞
发表日期：2022
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