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Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism

磷特异性液相色谱-电感耦合等离子体质谱法用于分析肌醇磷酸和肌醇焦磷酸代谢

doi:10.1042/BCJ20253151

Sprigg, Colleen; Whitfield, Hayley L; Leftwich, Philip T; Kuo, Hui-Fen; Chiou, Tzyy-Jen; Saiardi, Adolfo; Shipton, Megan L; Riley, Andrew M; Potter, Barry V L; Scholey, Dawn; Burton, Emily; Bedford, Mike R; Brearley, Charles A

代谢

发表日期：2025

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Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity

结构修饰配体和活性位点可塑性驱动的肌醇1,4,5-三磷酸激酶的底物混杂性

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-024-45917-5

Márquez-Moñino, María Ángeles; Ortega-García, Raquel; Whitfield, Hayley; Riley, Andrew M; Infantes, Lourdes; Garrett, Shane W; Shipton, Megan L; Brearley, Charles A; Potter, Barry V L; González, Beatriz

信号转导

发表日期：2024

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Crystal Structure and Enzymology of Solanum tuberosum Inositol Tris/Tetrakisphosphate Kinase 1 (StITPK1)

马铃薯肌醇三磷酸激酶1 (StITPK1) 的晶体结构和酶学

期刊:Biochemistry

影响因子:3

doi:10.1021/acs.biochem.3c00404

Whitfield, Hayley L; Rodriguez, Raquel Faba; Shipton, Megan L; Li, Arthur W H; Riley, Andrew M; Potter, Barry V L; Hemmings, Andrew M; Brearley, Charles A

信号转导

发表日期：2024

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Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP(5)

肌醇焦磷酸细胞信使 5-PP-InsP(5) 的简便合成和发光传感

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d2sc06812e

Shipton, Megan L; Jamion, Fathima A; Wheeler, Simon; Riley, Andrew M; Plasser, Felix; Potter, Barry V L; Butler, Stephen J

细胞生物学

发表日期：2023

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The inositol pyrophosphate 5-InsP(7) drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85Î±.

肌醇焦磷酸 5-InsP(7) 通过解除 PI3K p85α 的自身抑制结构域来驱动钠钾泵降解

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.abb8542

Chin Alfred C, Gao Zhe, Riley Andrew M, Furkert David, Wittwer Christopher, Dutta Amit, Rojas Tomas, Semenza Evan R, Felder Robin A, Pluznick Jennifer L, Jessen Henning J, Fiedler Dorothea, Potter Barry V L, Snyder Solomon H, Fu Chenglai

信号转导

发表日期：2020

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Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response

全基因组RNAi筛选揭示肌醇焦磷酸在I型干扰素反应中的关键作用

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1003981

Pulloor, Niyas Kudukkil; Nair, Sajith; McCaffrey, Kathleen; Kostic, Aleksandar D; Bist, Pradeep; Weaver, Jeremy D; Riley, Andrew M; Tyagi, Richa; Uchil, Pradeep D; York, John D; Snyder, Solomon H; García-Sastre, Adolfo; Potter, Barry V L; Lin, Rongtuan; Shears, Stephen B; Xavier, Ramnik J; Krishnan, Manoj N

Human

发表日期：2014

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Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain

硫柳汞通过IP(3)结合核心和抑制结构域内的半胱氨酸残基对IP(3)受体进行亚型选择性调控。

期刊:Biochemical Journal

影响因子:4.3

doi:10.1042/BJ20121600

Khan, Samir A; Rossi, Ana M; Riley, Andrew M; Potter, Barry V L; Taylor, Colin W

信号转导

发表日期：2013

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Inframolecular acid-base and coordination properties towards Na(+) and Mg(2+) of myo-inositol 1,3,4,5,6-pentakisphosphate: a structural approach to biologically relevant species

肌醇1,3,4,5,6-五磷酸酯对Na(+)和Mg(2+)的亚分子酸碱性和配位性质：一种研究生物学相关物种的结构方法

期刊:Dalton Transactions

影响因子:3.3

doi:10.1039/c2dt31807e

Veiga, Nicolás; Torres, Julia; Macho, Israel; Gómez, Kerman; Godage, Himali Y; Riley, Andrew M; Potter, Barry V L; González, Gabriel; Kremer, Carlos

发表日期：2013

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The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA

细胞内肌醇（焦）磷酸受体AtSPX1可与P1BS DNA相互结合。

A minimum catalytic unit for synthesis of InsP6 and 5-PP-InsP5 in Arabidopsis

拟南芥中 InsP6 和 5-PP-InsP5 合成的最小催化单元

Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism

磷特异性液相色谱-电感耦合等离子体质谱法用于分析肌醇磷酸和肌醇焦磷酸代谢

Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity

结构修饰配体和活性位点可塑性驱动的肌醇1,4,5-三磷酸激酶的底物混杂性

Crystal Structure and Enzymology of Solanum tuberosum Inositol Tris/Tetrakisphosphate Kinase 1 (StITPK1)

马铃薯肌醇三磷酸激酶1 (StITPK1) 的晶体结构和酶学

Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP(5)

肌醇焦磷酸细胞信使 5-PP-InsP(5) 的简便合成和发光传感

The inositol pyrophosphate 5-InsP(7) drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85Î±.

肌醇焦磷酸 5-InsP(7) 通过解除 PI3K p85α 的自身抑制结构域来驱动钠钾泵降解

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response

全基因组RNAi筛选揭示肌醇焦磷酸在I型干扰素反应中的关键作用

Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain

硫柳汞通过IP(3)结合核心和抑制结构域内的半胱氨酸残基对IP(3)受体进行亚型选择性调控。

Inframolecular acid-base and coordination properties towards Na(+) and Mg(2+) of myo-inositol 1,3,4,5,6-pentakisphosphate: a structural approach to biologically relevant species

肌醇1,3,4,5,6-五磷酸酯对Na(+)和Mg(2+)的亚分子酸碱性和配位性质：一种研究生物学相关物种的结构方法